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Development Status

Possibly Marketed Outside US

6

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Primary Target

NF-kappa B signaling pathway

4

Voltage-gated L-type calcium channel

4

fatty acid metabolic process

4

Serine/threonine-protein kinase AKT

2

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Highest Phase

Approved

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Phase III

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Approval Year

1958

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2007

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Condition

Age-related macular degeneration

4

Alzheimer’s disease

4

Coronary heart disease

4

Pregnancy

4

Bipolar depression

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Treatment Modality

Palliative

6

Primary

6

Preventing

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CNS Activity

CNS Active

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CNS Penetrant

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Originator

Farmer, E.H.|Van Den Heuvel, F.A.

4

Wiggers, H.A.L.

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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EPA CompTox

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EVMPD

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Salts, Hydrates, Esters, etc.

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Showing 1 - 6 of 6 results

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DOCONEXENT

ZAD9OKH9JC

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

TREHALOSE

B8WCK70T7I

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Status:

Possibly Marketed Outside US

First approved in 1958

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Serine/threonine-protein kinase AKT

Conditions:

Oculopharyngeal muscular dystrophy

Spinocerebellar ataxia, type 3

Dry eye syndrome

Bipolar depression

Trehalose, a naturally occurring disaccharide of glucose that appears to function in an anhydrobiotic capacity in many organisms. Bioblast Pharma study trehalose in Phase 2 for treating patients with Oculopharyngeal Muscular Dystrophy (OPMD) and spin...

ocerebellar ataxia, type 3. In OPMD trehalose prevents the aggregation of the pathological protein (PABPN1) in muscle cells, the hallmark of the disease, by stabilizing the protein, reducing the formation of protein aggregations, and promoting their clearance from cells through autophagy, thus preventing muscle cell death. Trehalose induces autophagy via mTOR independent pathway. It activates TFEB, a master controller of lysosomal biogenesis and autophagy, by inhibiting AKT which is a negative regulator of TFEB that acts by direct phosphorylation (and inhibition) of TFEB. In addition, trehalose protects cells from hypoxic and anoxic injury and suppresses protein aggregation. In vivo studies with trehalose show cellular and behavioral beneficial effects in animal models of neurodegenerative diseases. Trehalose was in phase III clinical trial to study if it was possible to use the drug as add-on therapy in Bipolar Depression. Also in combination with hyaluronate, it can be used to treat dry eye syndrome. Trehalose protects the epithelial cells on the ocular surface, improving their resistance to the daily stresses of dry environments and tear film changes in a dry eye.

Doconexent lysine salt

4RSC9PF5VC

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

DOCONEXENT SODIUM

295P7EPT4C

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

ETHYL DOCOSAHEXAENOATE

7PO7G8PA8M

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

NF-kappa B signaling pathway

Voltage-gated L-type calcium channel

fatty acid metabolic process

Conditions:

Alzheimer’s disease

Coronary heart disease

Age-related macular degeneration

Doconexent (Docosahexaenoic acid, DHA) is an omega-3 fatty acid that is a primary structural component of the human brain, cerebral cortex, skin, and retina. DHA is widely used as a food supplement, and is beleived to support healthy brain developmen...

t in young childred, prevent cardiovascular disease and cognitive decline during Alzheimer's disease. Most of these claims, however, were not supported by clinical trials. DHA spray is used as a tanner.

TREHALOSE DIHYDRATE

7YIN7J07X4

Export Data
Search for Structure

Status:

Possibly Marketed Outside US

First approved in 1958

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Serine/threonine-protein kinase AKT

Conditions:

Oculopharyngeal muscular dystrophy

Spinocerebellar ataxia, type 3

Dry eye syndrome

Bipolar depression

Trehalose, a naturally occurring disaccharide of glucose that appears to function in an anhydrobiotic capacity in many organisms. Bioblast Pharma study trehalose in Phase 2 for treating patients with Oculopharyngeal Muscular Dystrophy (OPMD) and spin...

ocerebellar ataxia, type 3. In OPMD trehalose prevents the aggregation of the pathological protein (PABPN1) in muscle cells, the hallmark of the disease, by stabilizing the protein, reducing the formation of protein aggregations, and promoting their clearance from cells through autophagy, thus preventing muscle cell death. Trehalose induces autophagy via mTOR independent pathway. It activates TFEB, a master controller of lysosomal biogenesis and autophagy, by inhibiting AKT which is a negative regulator of TFEB that acts by direct phosphorylation (and inhibition) of TFEB. In addition, trehalose protects cells from hypoxic and anoxic injury and suppresses protein aggregation. In vivo studies with trehalose show cellular and behavioral beneficial effects in animal models of neurodegenerative diseases. Trehalose was in phase III clinical trial to study if it was possible to use the drug as add-on therapy in Bipolar Depression. Also in combination with hyaluronate, it can be used to treat dry eye syndrome. Trehalose protects the epithelial cells on the ocular surface, improving their resistance to the daily stresses of dry environments and tear film changes in a dry eye.

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