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US Approved Rx

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Primary Target

Calcium sensing receptor

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2017

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Condition

Secondary hyperparathyroidism in adult patients with chronic kidney disease on hemodialysis

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KAI Pharmaceuticals

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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

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Other anti-parathyroid agents

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ETELCALCETIDE

60ME133FJB

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Status:

US Approved Rx (2017)

First approved in 2017

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Calcium sensing receptor

Conditions:

Secondary hyperparathyroidism in adult patients with chronic kidney disease on hemodialysis

Etelcalcetide (formerly velcalcetide, trade name Parsabiv) is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary ...

hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017. Etelcalcetide is a synthetic peptide calcium-sensing receptor agonist. It allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.

ETELCALCETIDE HYDROCHLORIDE

72PT5993DU

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Search for Structure

Status:

US Approved Rx (2017)

First approved in 2017

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Calcium sensing receptor

Conditions:

Secondary hyperparathyroidism in adult patients with chronic kidney disease on hemodialysis

Etelcalcetide (formerly velcalcetide, trade name Parsabiv) is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis. Etelcalcetide was approved (trade name Parsabiv) for the treatment of secondary ...

hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017. Etelcalcetide is a synthetic peptide calcium-sensing receptor agonist. It allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.

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