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Development Status

Investigational

2

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Primary Target

Histone deacetylase (HDAC1 and HDAC2)

2

Histone deacetylase 3

2

Lysine-specific histone demethylase 1

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Highest Phase

Phase I

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Approval Year

Unknown

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Condition

Advanced hematologic malignancies

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Colorectal cancer

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Hepatocellular carcinoma

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Urothelial carcinoma

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Treatment Modality

Primary

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Originator

Nycomed

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Chemical

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CAS

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FDA UNII

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PUBCHEM

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DRUG BANK

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INN

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Salts, Hydrates, Esters, etc.

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DOMATINOSTAT

264ARM7UXX

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histone deacetylase (HDAC1 and HDAC2)

Histone deacetylase 3

Lysine-specific histone demethylase 1

Conditions:

Colorectal cancer

Urothelial carcinoma

Advanced hematologic malignancies

Hepatocellular carcinoma

4SC-202 is an epigenetic oncology compound with a unique therapeutic profile, which was developed by biotechnology company: 4SC. 4SC-202 works as a selective inhibitor of LSD1 (lysine-specific demethylase 1) and HDAC (histone deacetylase) 1, 2 and 3....

4SC-202 also strengthens the endogenous immune response to cancer tissue. This compound demonstrated successfully completed Phase I of the clinical study, where it was proved safe and well tolerated in patients with advanced hematologic cancer. In addition, 4SC-202 shows substantial anti-tumor activity in a broad range of cancer cell lines including hepatocellular carcinoma, Urothelial Carcinoma Cell Lines and colorectal cancer.

DOMATINOSTAT TOSYLATE

9PW28FR8VD

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Search for Structure

Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histone deacetylase (HDAC1 and HDAC2)

Histone deacetylase 3

Lysine-specific histone demethylase 1

Conditions:

Colorectal cancer

Urothelial carcinoma

Advanced hematologic malignancies

Hepatocellular carcinoma

4SC-202 is an epigenetic oncology compound with a unique therapeutic profile, which was developed by biotechnology company: 4SC. 4SC-202 works as a selective inhibitor of LSD1 (lysine-specific demethylase 1) and HDAC (histone deacetylase) 1, 2 and 3....

4SC-202 also strengthens the endogenous immune response to cancer tissue. This compound demonstrated successfully completed Phase I of the clinical study, where it was proved safe and well tolerated in patients with advanced hematologic cancer. In addition, 4SC-202 shows substantial anti-tumor activity in a broad range of cancer cell lines including hepatocellular carcinoma, Urothelial Carcinoma Cell Lines and colorectal cancer.

HHS VULNERABILITY DISCLOSURE

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National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966


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