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Muscarinic acetylcholine receptor

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1911

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Eye diseases

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Pyloric stenosis

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Bayer

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BELLADONNA AND DERIVATIVES, PLAIN

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Belladonna alkaloids, semisynthetic, quaternary ammonium compounds

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METHYLATROPINIUM

80719I460H

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic acetylcholine receptor

Conditions:

Pyloric stenosis

Pyloric stenosis

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...

o its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

METHYLATROPINE BROMIDE

63IFT0IX9N

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic acetylcholine receptor

Conditions:

Pyloric stenosis

Pyloric stenosis

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...

o its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

METHYLATROPINE NITRATE

Q48D9J47K2

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic acetylcholine receptor

Conditions:

Pyloric stenosis

Pyloric stenosis

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...

o its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

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