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Primary Target

Glycine receptor subunit alpha-3

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Unknown

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Anxiety

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Hyperlipidemia

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Wormley, T.

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GELSEMINE

5Y13A78Z72

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Glycine receptor subunit alpha-3

Conditions:

Gelsemine is the principal alkaloid in Gelsemium sempervirens Ait. A single intrathecal injection of gelsemine produced potent and specific antinociception in formalin-induced tonic pain, bone cancer-induced mechanical allodynia, and spinal nerve lig...

ation-induced painful neuropathy. Gelsemine exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors. Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in PSNL mice; anterior cingulate cortex might play a role in the hypnotic effects of gelsemine.

GELSEMINE HYDROCHLORIDE

82N306UZML

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Glycine receptor subunit alpha-3

Conditions:

Gelsemine is the principal alkaloid in Gelsemium sempervirens Ait. A single intrathecal injection of gelsemine produced potent and specific antinociception in formalin-induced tonic pain, bone cancer-induced mechanical allodynia, and spinal nerve lig...

ation-induced painful neuropathy. Gelsemine exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors. Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in PSNL mice; anterior cingulate cortex might play a role in the hypnotic effects of gelsemine.

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