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Class (Stereo):
CHEMICAL (ACHIRAL)
Detanosal is antipyretic, analgesic and anti-inflammatory agent.
Status:
Investigational
Source:
INN:moxiraprine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Moxiraprine (also known as CM-30366) is aminopyridazine derivative with antidepressant activity. In preclinical studies Moxiraprine induced stereotyped behaviour and antagonized haloperidol-induced catalepsy in rats, after parenteral and oral administration. In 6-hydroxy dopamine (6-OHDA)-lesioned mice, Moxiraprine induced contralateral rotations and, when injected before 6-OHDA, protected mice against its neurotoxicity. Moxiraprine also provoked contralateral rotations when injected directly into the mouse right striatum. After parenteral injection, Moxiraprine slightly increased motility in mice, at least at low doses. The stereotypies and rotations (after intrastriatal injection) induced by Moxiraprine were antagonized by haloperidol, alpha-methyl-p-tyrosine and reserpine. The effects of Moxiraprine were compared to those of direct and indirect dopamine-like drugs. Bromocriptine induced a behavioural profile, which in most aspects, was qualitatively and quantitatively similar to that of Moxiraprine. Apomorphine was found slightly more potent than Moxiraprine, but in contrast to the latter, apomorphine-induced stereotypies were insensitive to alpha-methyl-p-tyrosine or reserpine. (+)-Amphetamine and nomifensine were less potent than Moxiraprine, and unlike Moxiraprine, induced ipsilateral rotations in 6-OHDA-lesioned mice.
Class (Stereo):
CHEMICAL (RACEMIC)
Ecipramidil is a peripheral and cerebral vasodilator.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Information in the literature related to the biological and/or pharmacological properties of molracetam is absent.
Status:
Investigational
Source:
Bol Chil Parasitol. 1983;38(3-4):42-9.: Not Applicable Veterinary clinical trial Completed Sheep Diseases
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Niclofolan (bayer 9015, Bilevon) is a biphenyl anthelmintic compound. Niclofolan is used orally towards the treatment of Fasciola hepatica infection. Niclofolan therapy achieved elimination of eggs from the feces and normalization of eosinophil counts, liver enzymes and Fasciola titers, suggesting eradication of biliary flukes. Niclofolan has also been used in the treatment of Paragonimus westermani in dogs and cats and P. iloktsuenensis in rats. It was proved that administration of daily dose of 1.0 mg/kg body weight for 3 days or in 2 doses of 2.0 mg/kg body weight by alternate days were evidently effective for the infected dogs, cats and rats with the lung flukes, and toxic manifestations were not found.
Class (Stereo):
CHEMICAL (ACHIRAL)
Nicanartine [MRZ 3124] is an antioxidant and cholesterol-lowering agent that was under development with Merz + Co. (later Merz Pharma) in Germany. Development of nicanartine for the treatment of atherosclerosis and reperfusion injury was discontinued at the phase I stage.
Class (Stereo):
CHEMICAL (ACHIRAL)
Etabenzarone is an anti-inflammatory and anticoagulant agent.
Status:
Investigational
Class (Stereo):
CHEMICAL (MIXED)
Ramciclane is a bicycloheptyloxyethanamine derivative that acts with sedative activity.
Status:
Investigational
Source:
INN:ftorpropazine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Ftorpropazine was developed as an antiarrhythmic agent that has never been marketed. Information about the current use of this drug is not available.
Status:
Investigational
Class (Stereo):
CHEMICAL (UNKNOWN)
Canbisol is dihydroxyhexahydrodibenzo(b,d)pyran derivative patented by pharmaceutical company Eli Lilly and Co. as antihypertensive agent. At the dosages studied, Canbisol reduced food consumption by rats.