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US Approved Rx

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Primary Target

Bacterial 70S ribosome

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Highest Phase

Approved

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Approval Year

2014

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Condition

Skin bacterial infections

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Skin infections

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Staphylococcal skin infections

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Unknown

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Treatment Modality

Curative

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Dong-A Pharmaceutical

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Chemical

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CAS

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CHEBI

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ANTIINFECTIVES FOR SYSTEMIC USE

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ANTIBACTERIALS FOR SYSTEMIC USE

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ATC Level 3

OTHER ANTIBACTERIALS

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ATC Level 4

Other antibacterials

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Salts, Hydrates, Esters, etc.

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TEDIZOLID

97HLQ82NGL

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Status:

US Approved Rx (2014)

First approved in 2014

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Bacterial 70S ribosome

Conditions:

Skin bacterial infections

Staphylococcal skin infections

Skin infections

Tedizolid phosphate is an oxazolidinone prodrug which in the body is dephosphorylated to the active compound tedizolid. The antibacterial activity of tedizolid is mediated by binding to the 50S subunit of the bacterial ribosome resulting in inhibitio...

n of protein synthesis. Tedizolid inhibits bacterial protein synthesis through a mechanism of action different from that of other non-oxazolidinone class antibacterial drugs; therefore, cross-resistance between tedizolid and other classes of antibacterial drugs is unlikely. Tedizolid is bacteriostatic against Gram Positive bacteria such as enterococci, staphylococci, and streptococci. No drug-drug interactions were identified with tedizolid.

TEDIZOLID PHOSPHATE

O7DRJ6R4DW

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Status:

US Approved Rx (2014)

First approved in 2014

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Bacterial 70S ribosome

Conditions:

Skin bacterial infections

Staphylococcal skin infections

Skin infections

Tedizolid phosphate is an oxazolidinone prodrug which in the body is dephosphorylated to the active compound tedizolid. The antibacterial activity of tedizolid is mediated by binding to the 50S subunit of the bacterial ribosome resulting in inhibitio...

n of protein synthesis. Tedizolid inhibits bacterial protein synthesis through a mechanism of action different from that of other non-oxazolidinone class antibacterial drugs; therefore, cross-resistance between tedizolid and other classes of antibacterial drugs is unlikely. Tedizolid is bacteriostatic against Gram Positive bacteria such as enterococci, staphylococci, and streptococci. No drug-drug interactions were identified with tedizolid.

TOREZOLID PHOSPHATE DISODIUM

0SVV6ZD7JQ

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Search for Structure

Status:

US Approved Rx (2014)

First approved in 2014

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bacterial 70S ribosome

Bacterial 70S ribosome

Conditions:

Skin bacterial infections

Staphylococcal skin infections

Skin infections

Tedizolid phosphate is an oxazolidinone prodrug which in the body is dephosphorylated to the active compound tedizolid. The antibacterial activity of tedizolid is mediated by binding to the 50S subunit of the bacterial ribosome resulting in inhibitio...

n of protein synthesis. Tedizolid inhibits bacterial protein synthesis through a mechanism of action different from that of other non-oxazolidinone class antibacterial drugs; therefore, cross-resistance between tedizolid and other classes of antibacterial drugs is unlikely. Tedizolid is bacteriostatic against Gram Positive bacteria such as enterococci, staphylococci, and streptococci. No drug-drug interactions were identified with tedizolid.

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