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Primary Target

AMP-activated protein kinase, AMPK

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Sodium/potassium-transporting ATPase subunit alpha-1

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apoptotic process

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Unknown

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Ischemic acute kidney injury

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Type 2 diabetes mellitus

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Primary

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Abbott

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A-769662

P68477CD2C

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

apoptotic process

Sodium/potassium-transporting ATPase subunit alpha-1

AMP-activated protein kinase, AMPK

Conditions:

Ischemic acute kidney injury

Type 2 diabetes mellitus

A-769662 stimulates partially purified rat liver AMPK with EC50 with 0.8 uM. A-769662 activates AMPK purified from multiple tissues and species in a dose-responsive manner with modest variations in observed EC50s. EC50s determined for A-769662 using ...

partially purified AMPK extracts from rat heart, rat muscle, or human embryonic kidney cells (HEKs) are 2.2 uM, 1.9 uM, or 1.1 uM, respectively. A 4 hours treatment of primary rat hepatocytes with A-769662 dose-dependently increases ACC phosphorylation, which correlated inhibition of fatty acid synthesis with IC50 of 3.2 uM. A-769662 also inhibits fatty acid sythesis in mouse hepatocytes with IC50 with 3.6 uM. A-769662 activates AMPK both allosterically and by inhibiting dephosphorylation of AMPK on Thr-172, similar to the effects of AMP. A-769662 inhibits proteasomal function by an AMPK-independent mechanism. A-769662 affects the in vitro activity of purified 26S proteasomes but not the in vitro activity of purified 20S proteasomes. A-769662 has toxic effects on MEF cells. A recent research shows A-769662 inhibited cell proliferation and DNA synthesis.

DIMETHYL (1-DIAZO-2-OXOPROPYL)PHOSPHONATE

96G79J0LR6

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

HHS VULNERABILITY DISCLOSURE

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