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Other

3

Possibly Marketed Outside US

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Primary Target

prostaglandin E synthase 2

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Unknown

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Condition

Urinary bladder diseases

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Palliative

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Originator

Wyeth

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Chemical

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PUBCHEM

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EPA CompTox

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Showing 1 - 4 of 4 results

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4-PHENOXYPIPERIDINE

AOF4M4L61Z

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

4-METHYL-5-NITROIMIDAZOLE

5PUL8BW840

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

FELBINAC ETHYL ESTER

978ZPS989U

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Status:

Possibly Marketed Outside US

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

prostaglandin E synthase 2

Conditions:

Urinary bladder diseases

Felbinac ethyl ester or ethyl 4-biphenylyl acetate (EBA) is a small molecule drug class of analgesics, antipyretics, nonsteroidal anti-inflammatories, phenylacetates. It is a prodrug of non-steroidal anti-inflammatory drug 4-biphenylylacetic acid (BP...

AA)- an active metabolite of EBA. The use of EBA instead of free BPAA in the form of lipid microspheres or solubilized in cyclodextrins enhances the anti-inflammatory effects of biphenylylacetic acid. Solubilization of EBA in hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) increases absorption and localized activation of the prodrug metabolic process in the epidermis when applied topically to the skin of rats and mice. Felbinac ethyl ester is a prostaglandin inhibitor. When intravenously administered felbinac ethyl ester incorporated in lipid microsphere at the onset of stone pain or vesical urgency in 54 patients with pain from urinary tract stones and 32 with vesical urgency after an operation on bladder or prostate be was found to be a useful drug for controlling stone pain and vesical urgency since an immediate effect, long durability and high response rates were obtained without severe side affects.

4-PHENOXYPIPERIDINE HYDROCHLORIDE

M89K01F27C

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

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