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CoA esters of acyl- and aryl-CoA esters formation

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Unknown

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Reye syndrome

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Preventing

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Emerson, W.S. et al.

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P-CHLOROBENZOIC ACID

IC7888DF4L

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

CoA esters of acyl- and aryl-CoA esters formation

Conditions:

p-Chlorobenzoic acid is a major metabolite of analgesic agent zomepirac sodium in rat (present as conjugates) and mouse and a minor one in monkey and man. It is a metabolite of antidepressant Lofepramine hydrochloride, and anxiolytic and a muscle rel...

axant Chlormezanone too. Sodium salt of p-Chlorobenzoic acid is used as a preservative. p-Chlorobenzoic acid may prove useful clinically to prevent and reverse the accumulation of toxic levels of acyl- and arylCoA esters. If the hepatic damage in Reye’s Syndrome is due to the dead-end formation of the CoA esters of acyl- and aryl-CoA esters, then p-chlorobenzoic acid may block their formation, thereby relieving the inhibitions of gluconeogenesis and urea synthesis and preventing some of the damage to the liver.

SODIUM P-CHLOROBENZOATE

WLB6A4A792

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

CoA esters of acyl- and aryl-CoA esters formation

Conditions:

p-Chlorobenzoic acid is a major metabolite of analgesic agent zomepirac sodium in rat (present as conjugates) and mouse and a minor one in monkey and man. It is a metabolite of antidepressant Lofepramine hydrochloride, and anxiolytic and a muscle rel...

axant Chlormezanone too. Sodium salt of p-Chlorobenzoic acid is used as a preservative. p-Chlorobenzoic acid may prove useful clinically to prevent and reverse the accumulation of toxic levels of acyl- and arylCoA esters. If the hepatic damage in Reye’s Syndrome is due to the dead-end formation of the CoA esters of acyl- and aryl-CoA esters, then p-chlorobenzoic acid may block their formation, thereby relieving the inhibitions of gluconeogenesis and urea synthesis and preventing some of the damage to the liver.

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