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Primary Target

Cytochrome b

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ubiquinol-cytochrome-c reductase activity

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Unknown

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Malaria

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Syngenta

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2-HYDROXYBENZONITRILE

51RSM8K1VZ

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

AZOXYSTROBIN

NYH7Y08IPM

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

ubiquinol-cytochrome-c reductase activity

Conditions:

Azoxystrobin is the first of a new class of pesticidal compounds called ß-methoxyacrylates, which are derived from the naturally-occurring strobilurins. Azoxystrobin is a broad spectrum fungicide with activity against several diseases on many edible ...

crops and ornamental plants. Some diseases controlled or prevented are rice blast, rusts, downy mildew, powdery mildew, late blight, apple scab, and Septoria. Azoxystrobin is marketed by Syngenta as single AS products under several trade names, the major ones for crop protection being: Amistar, Abound, Priori, Quadris, Dynasty for seed treatments, and Heritage for turf. Azoxystrobin (AZOX), a Qo inhibitor of mitochondrial respiratory complex III, exerts whole-body beneficial effects on the regulation of glucose and lipid homeostasis in high-fat diet-fed mice. Chronic treatment with AZOX reduced body weight and significantly improved glucose tolerance and insulin sensitivity in high-fat diet-fed mice. AZOX treatment resulted in decreased triacylglycerol accumulation and down-regulated the expression of genes involved in liver lipogenesis. AZOX increased glucose uptake in L6 myotubes and 3T3-L1 adipocytes and inhibited de novo lipogenesis in HepG2 cells.

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