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Investigational

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Gamma-secretase

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Unknown

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Chemical and Screening Sciences, and Discovery Neuroscience, Wyeth Research

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BEGACESTAT

3666C56BBU

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Status:

Investigational

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Gamma-secretase

Begacestat (GSI-953 or PF-5212362), a gamma-secretase inhibitor (GSI) that selectively inhibits cleavage of APP over Notch, was discovered for the treatment of Alzheimer's disease. The drug has shown promise results in phase I clinical trials, howeve...

r further studies were discontinued.

4-CHLOROBENZENESULFONYL CHLORIDE

H55O3362D6

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

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