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Other

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US Approved Rx

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Primary Target

Intermediate conductance calcium-activated potassium channel protein 4

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Approved

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Approval Year

1958

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Condition

Muscle spasm

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Primary

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McNeil Laboratories

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EPA CompTox

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ATC Level 1

MUSCULO-SKELETAL SYSTEM

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MUSCLE RELAXANTS

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ATC Level 3

MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS

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ATC Level 4

Oxazol, thiazine, and triazine derivatives

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CHLORZOXAZONE

H0DE420U8G

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Status:

US Approved Rx (2010)

First approved in 1958

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Intermediate conductance calcium-activated potassium channel protein 4

Conditions:

Chlorzoxazone is a centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisyna...

ptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. The clinical result is a reduction of the skeletal muscle spasm with relief of pain and increased mobility of the involved muscles. Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.

6-CHLORO-2,3-DIHYDROBENZOXAZOL-2-ONE

PG1JLE50LE

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

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