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ELPETRIGINE

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  1X64S9H3ZS

Status:
Investigational
Source:
INN:elpetrigine [INN]
Source URL:
https://ginas.ncats.nih.gov/ginas/app/substance/1X64S9H3ZS
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Sodium channel protein type II alpha subunit
27
Sodium channel protein type III alpha subunit
18
Voltage-gated L-type calcium channel
95
Voltage-gated N-type calcium channel alpha-1B subunit
14
Voltage-gated P/Q-type calcium channel alpha-1A subunit
1
Elpetrigine (GW293273 or JZP-4) is potent calcium and sodium channel blocker. In animal models, elpetrigine exerts anxiolytic, anticonvulsant, antidepressant and antimania effects. Jazz Pharmaceuticals is developing elpetrigine for the treatment of mood disorders and epilepsy.

5-Methylisoxazole-4-carboxylic acid

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BL2Q213Q2M

Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
NIH
NCATS
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