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Development Status

Investigational

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Other

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Primary Target

Serotonin 6 (5-HT6) receptor

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Highest Phase

Phase III

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Approval Year

Unknown

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Condition

Alzheimer’s disease

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Obesity

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Schizophrenia

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Treatment Modality

Primary

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CNS Activity

CNS Active

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Originator

Eli Lilly

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Chemical

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CAS

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PUBCHEM

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Showing 1 - 3 of 3 results

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IDALOPIRDINE

59WCJ0YNWM

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Serotonin 6 (5-HT6) receptor

Conditions:

Alzheimer’s disease

Idalopirdine (Lu AE58054) is a Serotonin 6 receptor (5-HT6) antagonist. Idalopirdine exrets good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. In rats idalopirdine potentiates the effects of acetyl...

cholinesterase inhibitor donepezil on two pharmacodynamic biomarkers associated with cognition, i.e. neuronal oscillations and extracellular ACh levels in the hippocampus. Such potentiation could contribute to the procognitive effects of idalopirdine observed in donepezil-treated Alzheimer's disease patients. The compound is being developed by Lundbeck as an adjunctive therapy with acetylcholinesterase inhibitor donepezil, and is in phase III development for the treatment of Alzheimer's disease in multiple countries worldwide. A phase II trial for the treatment of cognitive impairment associated with schizophrenia was conducted; however no recent reports of development for idalopirdine have been identified.

DIMETHYL(METHYLENE)AMMOUNIUM IODIDE

5C42I004S1

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

IDALOPIRDINE HYDROCHLORIDE

545BT5182Y

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Serotonin 6 (5-HT6) receptor

Conditions:

Alzheimer’s disease

Idalopirdine (Lu AE58054) is a Serotonin 6 receptor (5-HT6) antagonist. Idalopirdine exrets good oral bioavailability and robust efficacy in a rat model of cognitive impairment in schizophrenia. In rats idalopirdine potentiates the effects of acetyl...

cholinesterase inhibitor donepezil on two pharmacodynamic biomarkers associated with cognition, i.e. neuronal oscillations and extracellular ACh levels in the hippocampus. Such potentiation could contribute to the procognitive effects of idalopirdine observed in donepezil-treated Alzheimer's disease patients. The compound is being developed by Lundbeck as an adjunctive therapy with acetylcholinesterase inhibitor donepezil, and is in phase III development for the treatment of Alzheimer's disease in multiple countries worldwide. A phase II trial for the treatment of cognitive impairment associated with schizophrenia was conducted; however no recent reports of development for idalopirdine have been identified.

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