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Development Status

US Approved Rx

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Primary Target

Serotonin 1a (5-HT1a) receptor

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Highest Phase

Approved

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Approval Year

1986

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Condition

Anxiety

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Primary

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CNS Activity

CNS Active

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Originator

Bristol-Myers Squibb

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Chemical

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CHEBI

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DRUG BANK

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ATC Level 1

NERVOUS SYSTEM

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PSYCHOLEPTICS

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ATC Level 3

ANXIOLYTICS

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ATC Level 4

Azaspirodecanedione derivatives

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Principal Form

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Salts, Hydrates, Esters, etc.

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BUSPIRONE

TK65WKS8HL

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Status:

US Approved Rx (2014)

First approved in 1986

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Serotonin 1a (5-HT1a) receptor

Conditions:

Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. Animal studies have suggested antianxiety activity and the absence of abuse potential. Behavioural, electrophysiological and receptor binding experiments gradua...

lly led to the idea that buspirone owes much of its anxiolytic activity to its ability to attenuate central 5-hydroxytryptamine neurotransmission. In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. The drug was approved by FDA for the treatment of anxiety.

BUSPIRONE HYDROCHLORIDE

207LT9J9OC

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Search for Structure

Status:

US Approved Rx (2014)

First approved in 1986

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Serotonin 1a (5-HT1a) receptor

Conditions:

Buspirone is the first of a new class of anxioselective agents, the azaspirodecanediones. Animal studies have suggested antianxiety activity and the absence of abuse potential. Behavioural, electrophysiological and receptor binding experiments gradua...

lly led to the idea that buspirone owes much of its anxiolytic activity to its ability to attenuate central 5-hydroxytryptamine neurotransmission. In vitro preclinical studies have shown that buspirone has a high affinity for serotonin (5-HT1A) receptors. Some studies do suggest that buspirone may have indirect effects on other neurotransmitter systems. Buspirone differs from typical benzodiazepine anxiolytics in that it does not exert anticonvulsant or muscle relaxant effects. It also lacks the prominent sedative effect that is associated with more typical anxiolytics. The drug was approved by FDA for the treatment of anxiety.

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