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Development Status

US Previously Marketed

3

Other

1

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Primary Target

S-adenosylmethionine synthetase (MAT 1 and MAT 2)

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Highest Phase

Approved

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Approval Year

1945

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Unknown

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Condition

AIDS vacuolar myelopathy

3

Alkaline urine

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Skin irritation in incontinent adults and diaper rash in infants

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Treatment Modality

Primary

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CNS Activity

CNS Penetrant

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Originator

Emerson, O.H.|Kirk, P.L.|Schmidt, C.L.A.

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Substance Class

Chemical

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CAS

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FDA UNII

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PUBCHEM

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EPA CompTox

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CHEBI

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ATC Level 1

VARIOUS

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ALL OTHER THERAPEUTIC PRODUCTS

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ATC Level 3

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ATC Level 4

Antidotes

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Substance Form

Principal Form

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Salts, Hydrates, Esters, etc.

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Showing 1 - 4 of 4 results

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ETHYL CARBONATE

3UA92692HG

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

METHIONINE

AE28F7PNPL

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Status:

US Previously Marketed

First approved in 1945

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

S-adenosylmethionine synthetase (MAT 1 and MAT 2)

Conditions:

AIDS vacuolar myelopathy

Skin irritation in incontinent adults and diaper rash in infants

Methionine is an non-polar, aliphatic, essential α-amino acid that is used in the biosynthesis of proteins. High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found...

in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. However, it is the combination of methionine and cystine which is considered for completeness of a protein. There is scientific evidence that restricting methionine consumption can increase lifespans in some animals. However, since methionine is an essential amino acid, it cannot be entirely removed from animals' diets without disease or death occurring over time. For example, rats fed a diet without methionine developed steatohepatitis (fatty liver), anemia and lost two thirds of their body weight over 5 weeks. Administration of methionine ameliorated the pathological consequences of methionine deprivation.

METHIONINE HYDROCHLORIDE

99JNR46OKX

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Status:

US Previously Marketed

First approved in 1945

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

S-adenosylmethionine synthetase (MAT 1 and MAT 2)

Conditions:

AIDS vacuolar myelopathy

Skin irritation in incontinent adults and diaper rash in infants

Methionine is an non-polar, aliphatic, essential α-amino acid that is used in the biosynthesis of proteins. High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found...

in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. However, it is the combination of methionine and cystine which is considered for completeness of a protein. There is scientific evidence that restricting methionine consumption can increase lifespans in some animals. However, since methionine is an essential amino acid, it cannot be entirely removed from animals' diets without disease or death occurring over time. For example, rats fed a diet without methionine developed steatohepatitis (fatty liver), anemia and lost two thirds of their body weight over 5 weeks. Administration of methionine ameliorated the pathological consequences of methionine deprivation.

METHIONINE SODIUM

2YR4SPE61X

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Status:

US Previously Marketed

First approved in 1945

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

S-adenosylmethionine synthetase (MAT 1 and MAT 2)

Conditions:

AIDS vacuolar myelopathy

Skin irritation in incontinent adults and diaper rash in infants

Methionine is an non-polar, aliphatic, essential α-amino acid that is used in the biosynthesis of proteins. High levels of methionine can be found in eggs, sesame seeds, Brazil nuts, fish, meats and some other plant seeds; methionine is also found...

in cereal grains. Most fruits and vegetables contain very little of it. Most legumes are also low in methionine. However, it is the combination of methionine and cystine which is considered for completeness of a protein. There is scientific evidence that restricting methionine consumption can increase lifespans in some animals. However, since methionine is an essential amino acid, it cannot be entirely removed from animals' diets without disease or death occurring over time. For example, rats fed a diet without methionine developed steatohepatitis (fatty liver), anemia and lost two thirds of their body weight over 5 weeks. Administration of methionine ameliorated the pathological consequences of methionine deprivation.

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