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Development Status

Possibly Marketed Outside US

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Primary Target

Trace amine-associated receptor 5

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2017

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Chemical

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Showing 1 - 4 of 4 results

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TRIMETHYLAMINE

LHH7G8O305

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trace amine-associated receptor 5

Trimethylamine (or TMA) a tertiary amine, is synthesized by the action of microbial enzymes in humans. The decrease of TMA metabolism and excessive TMA excretion cause the disease trimethylaminuria and some other diseases associated with the abnormal...

level of TMA, e.g., obesity, diabetes, cardiovascular diseases. It was shown, that TMS is a full agonist of human trace amine-associated receptor 5, TAAR5. In addition, TMA is a precursor of N-oxide form, an emergent biomarker of human health that can lead to renal diseases, neurological disorders, and cancer.

SOLKETAL

3XK098O8ZW

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (RACEMIC)

TRIMETHYLAMMONIUM BROMIDE

GM9DGY2VED

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trace amine-associated receptor 5

Trimethylamine (or TMA) a tertiary amine, is synthesized by the action of microbial enzymes in humans. The decrease of TMA metabolism and excessive TMA excretion cause the disease trimethylaminuria and some other diseases associated with the abnormal...

level of TMA, e.g., obesity, diabetes, cardiovascular diseases. It was shown, that TMS is a full agonist of human trace amine-associated receptor 5, TAAR5. In addition, TMA is a precursor of N-oxide form, an emergent biomarker of human health that can lead to renal diseases, neurological disorders, and cancer.

TRIMETHYLAMINE HYDROCHLORIDE

UW38SRM77K

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Status:

Possibly Marketed Outside US

First approved in 2017

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Trace amine-associated receptor 5

Trimethylamine (or TMA) a tertiary amine, is synthesized by the action of microbial enzymes in humans. The decrease of TMA metabolism and excessive TMA excretion cause the disease trimethylaminuria and some other diseases associated with the abnormal...

level of TMA, e.g., obesity, diabetes, cardiovascular diseases. It was shown, that TMS is a full agonist of human trace amine-associated receptor 5, TAAR5. In addition, TMA is a precursor of N-oxide form, an emergent biomarker of human health that can lead to renal diseases, neurological disorders, and cancer.

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