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US Approved Rx

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Primary Target

Dihydrofolate reductase

5

Thymidylate synthase

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Highest Phase

Approved

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Approval Year

1952

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Condition

Advanced colorectal cancer

5

Megaloblastic anemia

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Osteosarcoma

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Treatment Modality

Palliative

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Secondary

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CNS Activity

CNS Penetrant

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Originator

Burroughs Wellcome Fund

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Chemical

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Code System

CAS

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FDA UNII

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PUBCHEM

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DRUG BANK

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EPA CompTox

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ATC Level 1

VARIOUS

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ATC Level 2

ALL OTHER THERAPEUTIC PRODUCTS

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ATC Level 3

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ATC Level 4

Detoxifying agents for antineoplastic treatment

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Substance Form

Salts, Hydrates, Esters, etc.

4

Principal Form

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Showing 1 - 5 of 5 results

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LEUCOVORIN

Q573I9DVLP

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Status:

US Approved Rx (2000)

First approved in 1952

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Dihydrofolate reductase

Thymidylate synthase

Conditions:

Megaloblastic anemia

Advanced colorectal cancer

Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate. Leucov...

orin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anticancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate). Leucovorin is also used by itself to treat certain anemia problems when folic acid deficiency is present.

LEUCOVORIN MONOSODIUM

DR33Q67R37

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Status:

US Approved Rx (2000)

First approved in 1952

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Dihydrofolate reductase

Thymidylate synthase

Conditions:

Megaloblastic anemia

Advanced colorectal cancer

Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate. Leucov...

orin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anticancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate). Leucovorin is also used by itself to treat certain anemia problems when folic acid deficiency is present.

LEUCOVORIN CALCIUM PENTAHYDRATE

R3W57OBQ5W

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Status:

US Approved Rx (2000)

First approved in 1952

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Dihydrofolate reductase

Thymidylate synthase

Conditions:

Megaloblastic anemia

Advanced colorectal cancer

Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate. Leucov...

orin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anticancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate). Leucovorin is also used by itself to treat certain anemia problems when folic acid deficiency is present.

LEUCOVORIN CALCIUM

RPR1R4C0P4

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Search for Structure

Status:

US Approved Rx (2000)

First approved in 1952

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Dihydrofolate reductase

Thymidylate synthase

Conditions:

Megaloblastic anemia

Advanced colorectal cancer

Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate. Leucov...

orin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anticancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate). Leucovorin is also used by itself to treat certain anemia problems when folic acid deficiency is present.

LEUCOVORIN SODIUM

4MXU9LJS4Q

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Search for Structure

Status:

US Approved Rx (2000)

First approved in 1952

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Dihydrofolate reductase

Thymidylate synthase

Conditions:

Megaloblastic anemia

Advanced colorectal cancer

Leucovorin is a compound similar to folic acid, which is a necessary vitamin. It has been around and in use for many decades. Leucovorin is a medication frequently used in combination with the chemotherapy drugs fluoruracil and methotrexate. Leucov...

orin is not a chemotherapy drug itself, however it is used in addition to these chemotherapy drugs to enhance anticancer effects (with fluorouracil) or to help prevent or lessen side effects (with methotrexate). Leucovorin is also used by itself to treat certain anemia problems when folic acid deficiency is present.

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