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2

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fetal-globin synthesis

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gamma-globin synthesis

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Unknown

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Childrens Hospital of Oakland

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Showing 1 - 3 of 3 results

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ISOBUTYRAMIDE

82UOE7B38Z

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Status:

Designated

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

gamma-globin synthesis

fetal-globin synthesis

Isobutyramide (VX-366) is an orally available branched chain amide that may offer an alternative to current treatments for beta-hemoglobinopathy. Isobutyramide has been shown to increase fetal hemoglobin (HbF) in patients with beta-hemoglobinopathies...

. Isobutyramide was originated at the Children's Hospital Oakland Research Institute which, in 1993, granted exclusive worldwide rights for the agent to Vertex. However, development of Isobutyramide has been discontinued for sickle cell anaemia and thalassaemia.

8-HYDROXY-1-METHYLQUINOLINIUM METHYL SULFATE

3D7I3E60ZR

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

8-hydroxy-1-methylquinolin-1-ium iodide

RBQ22Y9UTQ

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Status:

Other

Class (Stereo):

CHEMICAL (ACHIRAL)

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