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GABA-gated chloride channel rdl-A285, C. felis (UniProtKB - V9Z984)

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GABA-gated chloride channel rdl-S285, C. felis (UniProtKB - V9ZCF2)

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Showing 1 - 4 of 4 results

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SAROLANER

DM113FTW7F

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Status:

Possibly Marketed Outside US

First approved in 2016

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

GABA-gated chloride channel rdl-A285, C. felis (UniProtKB - V9Z984)

GABA-gated chloride channel rdl-S285, C. felis (UniProtKB - V9ZCF2)

Conditions:

Tick infestations

Flea infestations

Sarolaner is a member of the isoxazoline class of parasiticides. It is sold under the brand name Simparica, indicated for the treatment of tick infestations (Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus and Rhipicephalus sanguineus), as ...

well as of flea infestations (Ctenocephalides felis and Ctenocephalides canis) in dogs. The primary target of action of sarolaner in insects and acarines is functional blockade of ligand-gated chloride channels (GABA-receptors and glutamate-receptors). Sarolaner blocks GABA- and glutamate-gated chloride channels in the central nervous system of insects and acarines. Disruption of these receptors by sarolaner prevents the uptake of chloride ions by GABA and glutamate gated ion channels, thus resulting in increased nerve stimulation and death of the target parasite. Sarolaner exhibits higher functional potency to block insect/acarine receptors compared to mammalian receptors.

MAROPITANT

4XE2T9H4DH

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Substance-P receptor

Conditions:

Motion sickness in dogs

Maropitant (trade name Cerenia in the U.S. and other countries), used as maropitant citrate is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approv...

ed by the FDA in 2007 for use in dogs, and was later approved for use in cats. Maropitant also has anti-nociceptive (analgesic) properties. Maropitant inhibits binding of substance P to NK-1 receptors. Substance P is an emetogen experimentally, and is found endogenously, along with NK-1 receptors, in the emetic center, chemoreceptor trigger zone, and in vagal afferent nerves in the gastrointestinal tract.

MAROPITANT CITRATE ANHYDROUS

19364RWW06

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Substance-P receptor

Conditions:

Motion sickness in dogs

Maropitant (trade name Cerenia in the U.S. and other countries), used as maropitant citrate is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approv...

ed by the FDA in 2007 for use in dogs, and was later approved for use in cats. Maropitant also has anti-nociceptive (analgesic) properties. Maropitant inhibits binding of substance P to NK-1 receptors. Substance P is an emetogen experimentally, and is found endogenously, along with NK-1 receptors, in the emetic center, chemoreceptor trigger zone, and in vagal afferent nerves in the gastrointestinal tract.

MAROPITANT CITRATE

LXN6S3999X

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Status:

Possibly Marketed Outside US

First approved in 2007

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Substance-P receptor

Conditions:

Motion sickness in dogs

Maropitant (trade name Cerenia in the U.S. and other countries), used as maropitant citrate is a neurokinin (NK1) receptor antagonist, which was developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approv...

ed by the FDA in 2007 for use in dogs, and was later approved for use in cats. Maropitant also has anti-nociceptive (analgesic) properties. Maropitant inhibits binding of substance P to NK-1 receptors. Substance P is an emetogen experimentally, and is found endogenously, along with NK-1 receptors, in the emetic center, chemoreceptor trigger zone, and in vagal afferent nerves in the gastrointestinal tract.

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