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Originator

Thistle, J.L.

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Pfizer

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Eli Lilly

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Merck

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GlaxoSmithKline

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US Previously Marketed

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Highest Phase

Approved

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Approval Year

1985

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Condition

Gallstones

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Treatment Modality

Curative

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Chemical

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Mixture

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Code System

ChEMBL

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FDA UNII

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CAS

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CHEBI

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DAILYMED

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Principal Form

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Salts, Hydrates, Esters, etc.

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MONOCTANOIN

VFU0OU98LO

Status:

US Previously Marketed

First approved in 1985

Class:

MIXTURE

Conditions:

Glyceryl 1-caprylate (Monooctanoin, Capmul 8210), a semisynthetic esterified glycerol, a cholesterol solvent, that has been used for the dissolution of retained cholesterol gallstones following cholecystectomy. Bile duct infusion of monooctanoin is a...

ssociated with little toxicity, although potentially serious problems can result from absorption of the drug or tissue infiltration. Gastrointestinal side effects such as anorexia, nausea, vomiting, diarrhea, and abdominal pain have been reported most commonly. Complete gallstone dissolution has occurred in approximately 50-75 percent of patients receiving monooctanoin. Although mechanical stone removal is still considered to be the treatment of choice for retained gallstones, monooctanoin use appeared promising for stone dissolution in patients in whom mechanical removal has been unsuccessful or is impossible. Monoctanoin was approved by the U.S. Food and Drug Administration (FDA) on Oct 29, 1985. It was developed and marketed as Moctanin® by ETHITEK in US.

GLYCERYL 1-CAPRYLATE

MCF579Z59B

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Status:

US Previously Marketed

First approved in 1985

Class (Stereo):

CHEMICAL (RACEMIC)

Conditions:

Glyceryl 1-caprylate (Monooctanoin, Capmul 8210), a semisynthetic esterified glycerol, a cholesterol solvent, that has been used for the dissolution of retained cholesterol gallstones following cholecystectomy. Bile duct infusion of monooctanoin is a...

ssociated with little toxicity, although potentially serious problems can result from absorption of the drug or tissue infiltration. Gastrointestinal side effects such as anorexia, nausea, vomiting, diarrhea, and abdominal pain have been reported most commonly. Complete gallstone dissolution has occurred in approximately 50-75 percent of patients receiving monooctanoin. Although mechanical stone removal is still considered to be the treatment of choice for retained gallstones, monooctanoin use appeared promising for stone dissolution in patients in whom mechanical removal has been unsuccessful or is impossible. Monoctanoin was approved by the U.S. Food and Drug Administration (FDA) on Oct 29, 1985. It was developed and marketed as Moctanin® by ETHITEK in US.

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