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Originator

Sheppard et al.

2

Pfizer

420

Eli Lilly

237

Merck

216

GlaxoSmithKline

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Development Status

US Previously Marketed

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Approval Year

1950

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Chemical

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CAS

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EPA CompTox

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FDA UNII

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DRUG BANK

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VARIOUS

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THERAPEUTIC RADIOPHARMACEUTICALS

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ANTIINFLAMMATORY AGENTS

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ATC Level 4

Other antiinflammatory therapeutic radiopharmaceuticals

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GOLD AU-198

027828ZV5Q

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Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ACHIRAL)

The therapeutic use of radioactive colloidal gold Gold Au-198 (Au198) was first described by Sheppard et al., who reported on intravenous use in 1947. Its possibilities for the treatment of various malignant processes have been explored in great vari...

ation. Gold Au-198 is an antineoplastic, diagnostic aid (liver imaging) and radioactive agent. Thus, intracavitary instillation of colloidal radioactive gold Au-198 was used for treatment of patients with multiple papillomata of the bladder. Approximately 300 mc. of gold was instilled into the bladder for four to six hours to deliver a dose of about 4,000 to 5,000 r to the bladder epithelium. The treatment had no harmful side-effects locally or on the general condition of the patient. It was also used to estimate the hepatic blood flow in children with active or progressive chronic hepatitis. Gold Au-198 was used in the combination therapy of rectal cancer.

GOLD TRICHLORIDE AU-198

55X405F87A

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Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ACHIRAL)

The therapeutic use of radioactive colloidal gold Gold Au-198 (Au198) was first described by Sheppard et al., who reported on intravenous use in 1947. Its possibilities for the treatment of various malignant processes have been explored in great vari...

ation. Gold Au-198 is an antineoplastic, diagnostic aid (liver imaging) and radioactive agent. Thus, intracavitary instillation of colloidal radioactive gold Au-198 was used for treatment of patients with multiple papillomata of the bladder. Approximately 300 mc. of gold was instilled into the bladder for four to six hours to deliver a dose of about 4,000 to 5,000 r to the bladder epithelium. The treatment had no harmful side-effects locally or on the general condition of the patient. It was also used to estimate the hepatic blood flow in children with active or progressive chronic hepatitis. Gold Au-198 was used in the combination therapy of rectal cancer.

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