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Originator

Patil, V.D.|Nayak, U.R.|Dev, S.

2

Pfizer

420

Eli Lilly

239

Merck

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GlaxoSmithKline

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Androgen Receptor

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Bile acid receptor FXR

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GUGGULSTERONE, (E)-

9B259YE66O

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bile acid receptor

Bile acid receptor FXR

Androgen Receptor

Mineralocorticoid receptor

Pregnane X receptor

Glucocorticoid receptor

Conditions:

(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in chole...

sterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator. Both Guggulsterone isomers were demonstrated to suppress lipopolysaccharide-induced inflammation by inhibiting IκB-α degradation and NF-κB activation. GS has medicinal properties such as anti-inflammatory, hepatoprotective, muscle relaxing, hypocholesterolemic and anti-obesity, antimycobacterial, antischistomal, larvicidal, and molluscicida.

GUGGULSTERONE, (Z)-

6CST3U34GN

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Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Bile acid receptor

Bile acid receptor FXR

Androgen Receptor

Mineralocorticoid receptor

Pregnane X receptor

Glucocorticoid receptor

Conditions:

(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in chole...

sterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator. Both Guggulsterone isomers were demonstrated to suppress lipopolysaccharide-induced inflammation by inhibiting IκB-α degradation and NF-κB activation. GS has medicinal properties such as anti-inflammatory, hepatoprotective, muscle relaxing, hypocholesterolemic and anti-obesity, antimycobacterial, antischistomal, larvicidal, and molluscicida.

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