Inxight Drugs

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Return Home Inxight Drugs

Home
Browse Drugs
Search
- Structure Search
- Sequence Search
Downloads
About

Show Filters

Hide Filters

Originator

Organ.-chem. Institut d. Techn. Hochschule Danzig-Langfuhr

3

Pfizer

420

Eli Lilly

237

Merck

216

GlaxoSmithKline

193

All Match

Any Match

Exclude Selected

Exclude Selected

Development Status

US Previously Marketed

3

All Match

Any Match

Exclude Selected

Exclude Selected

Primary Target

Cannabinoid CB1 receptor

3

GABA-A receptor; anion channel

3

Glutamate [NMDA] receptor

3

Transient receptor potential cation channel subfamily M member 1

3

Transient receptor potential cation channel subfamily M member 3

3

All Match

Any Match

Exclude Selected

Exclude Selected

Highest Phase

Phase IV

3

All Match

Any Match

Exclude Selected

Exclude Selected

Approval Year

1950

3

All Match

Any Match

Exclude Selected

Exclude Selected

Condition

Autism

3

Bipolar disorder

3

Major depressive disorder

3

Marijuana dependence

3

Obsessive-compulsive disorder

3

All Match

Any Match

Exclude Selected

Exclude Selected

Treatment Modality

Primary

3

All Match

Any Match

Exclude Selected

Exclude Selected

CNS Activity

CNS Active

3

All Match

Any Match

Exclude Selected

Exclude Selected

Substance Class

Chemical

3

All Match

Any Match

Exclude Selected

Exclude Selected

Code System

CAS

3

EPA CompTox

3

FDA UNII

3

PUBCHEM

3

WIKIPEDIA

3

All Match

Any Match

Exclude Selected

Exclude Selected

Substance Form

Salts, Hydrates, Esters, etc.

2

Principal Form

1

All Match

Any Match

Exclude Selected

Exclude Selected

Showing 1 - 3 of 3 results

First page disabled
Previous page disabled
1
Next page disabled
Next page disabled

Pregnenolone

73R90F7MQ8

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Cannabinoid CB1 receptor

Transient receptor potential cation channel subfamily M member 1

GABA-A receptor; anion channel

Glutamate [NMDA] receptor

Transient receptor potential cation channel subfamily M member 3

Conditions:

Obsessive-compulsive disorder

Major depressive disorder

Marijuana dependence

Bipolar disorder

Spatial memory disorder

Pregnenolone sulfate is an endogenous neurosteroid with excitatory effects in the brain, acting as a potent negative allosteric modulator of the GABAA receptor, a positive allosteric modulator of the NMDA receptor, and activator of transient receptor...

potential cation channel TRPM1 and TRPM3. In the model of schizophrenia, treatment with pregnenolone sulfate normalized the hyperlocomotion and stereotypic bouts, and rescued the PPI deficits of dopamine transporter knockout mice. Promnesic properties of pregnenolone sulfate were demonstrated in rat models of spatial memory performance.

PREGNENOLONE ACETATE

0G0WWV404B

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Cannabinoid CB1 receptor

Transient receptor potential cation channel subfamily M member 1

GABA-A receptor; anion channel

Glutamate [NMDA] receptor

Transient receptor potential cation channel subfamily M member 3

Conditions:

Obsessive-compulsive disorder

Major depressive disorder

Marijuana dependence

Bipolar disorder

Spatial memory disorder

Pregnenolone sulfate is an endogenous neurosteroid with excitatory effects in the brain, acting as a potent negative allosteric modulator of the GABAA receptor, a positive allosteric modulator of the NMDA receptor, and activator of transient receptor...

potential cation channel TRPM1 and TRPM3. In the model of schizophrenia, treatment with pregnenolone sulfate normalized the hyperlocomotion and stereotypic bouts, and rescued the PPI deficits of dopamine transporter knockout mice. Promnesic properties of pregnenolone sulfate were demonstrated in rat models of spatial memory performance.

PREGNENOLONE SULFATE

04Y4D91RG0

Export Data
Search for Structure

Status:

US Previously Marketed

First approved in 1950

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Cannabinoid CB1 receptor

Transient receptor potential cation channel subfamily M member 1

GABA-A receptor; anion channel

Glutamate [NMDA] receptor

Transient receptor potential cation channel subfamily M member 3

Conditions:

Obsessive-compulsive disorder

Major depressive disorder

Marijuana dependence

Bipolar disorder

Spatial memory disorder

Pregnenolone sulfate is an endogenous neurosteroid with excitatory effects in the brain, acting as a potent negative allosteric modulator of the GABAA receptor, a positive allosteric modulator of the NMDA receptor, and activator of transient receptor...

potential cation channel TRPM1 and TRPM3. In the model of schizophrenia, treatment with pregnenolone sulfate normalized the hyperlocomotion and stereotypic bouts, and rescued the PPI deficits of dopamine transporter knockout mice. Promnesic properties of pregnenolone sulfate were demonstrated in rat models of spatial memory performance.

HHS VULNERABILITY DISCLOSURE

For language access assistance, contact the NCATS Public Information Officer

National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966


			version 1.1