U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1 - 10 of 10 results

Status:
Investigational
Source:
INN:pyrimitate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Pyrimitate is a pyrimidinyl thiophosphate derivative patented by Imperial Chemical Industries Ltd. as an insecticide and acaricide
Status:
Investigational
Source:
INN:cetamolol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cetamolol is a beta adrenergic antagonist with intrinsic sympathomimetic activity, patented by Imperial Chemical Industries Ltd for cardiovascular disease treatment. The average plasma half-life of cetamolol is 6.4 hours in humans and peak serum levels are reached 1 to 2 hours after drug intake; oral doses as low as 10 mg produced significant reductions in exercise-induced tachycardia 24 hours after drug administration. Cetamolol is approximately three times as potent as atenolol in blocking exercise-induced tachycardia.
Status:
Investigational
Source:
INN:levomoprolol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Moprolol is a beta-adrenergic antagonist, or beta blocker, typically prescribed to treat hypertension, high blood pressure, angina pectoris, arrhythmias, anxiety, and glaucoma. Moprolol has been the subject for many clinical trials to study the effect moprolol has on both blood pressure and glaucoma. In clinical trials, Moprolol shows some effect on lowering blood pressure with no effects on the heart rate. Moprolol is currently off the market, most likely due to the manufacturer being in violation of US good manufacturing practices.
Status:
Investigational
Source:
INN:brofezil
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Brofezil (ICI 54594) is an ibuprofen derivative with anti-inflammatory and analgesic activity.
Status:
Investigational
Source:
INN:tetronasin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Tetronasin is a furanone derivative patented by Imperial Chemical Industries Ltd. as antibiotic and feed additive for ruminants. Tetronasin acts as divalent antiporter that binds preferentially with Ca2+ or Mg2+ and inhibits anaerobic fungi and Gram-negative bacteria in vitro.
Status:
Investigational
Source:
INN:thiambutosine [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Thiambutosine is a carbanilide derivative patented by Imperial Chemical Industries Ltd. as the antituberculous agent. In vitro, the resistance of Mycobacterium tuberculosis H37Rv to Thiambutosine develops more slowly than resistance to streptomycin, p-aminosalicylic acid, or isoniazid. A sub-inhibiting concentration of Thiambutosine with either streptomycin or isoniazid considerably retards the emergence of strains resistant to these two agents.
Status:
Investigational
Source:
INN:levomoprolol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Moprolol is a beta-adrenergic antagonist, or beta blocker, typically prescribed to treat hypertension, high blood pressure, angina pectoris, arrhythmias, anxiety, and glaucoma. Moprolol has been the subject for many clinical trials to study the effect moprolol has on both blood pressure and glaucoma. In clinical trials, Moprolol shows some effect on lowering blood pressure with no effects on the heart rate. Moprolol is currently off the market, most likely due to the manufacturer being in violation of US good manufacturing practices.
Status:
Investigational
Source:
INN:brofezil
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Brofezil (ICI 54594) is an ibuprofen derivative with anti-inflammatory and analgesic activity.
Status:
Investigational
Source:
INN:tetronasin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Tetronasin is a furanone derivative patented by Imperial Chemical Industries Ltd. as antibiotic and feed additive for ruminants. Tetronasin acts as divalent antiporter that binds preferentially with Ca2+ or Mg2+ and inhibits anaerobic fungi and Gram-negative bacteria in vitro.
Status:
Investigational
Source:
INN:cetamolol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Cetamolol is a beta adrenergic antagonist with intrinsic sympathomimetic activity, patented by Imperial Chemical Industries Ltd for cardiovascular disease treatment. The average plasma half-life of cetamolol is 6.4 hours in humans and peak serum levels are reached 1 to 2 hours after drug intake; oral doses as low as 10 mg produced significant reductions in exercise-induced tachycardia 24 hours after drug administration. Cetamolol is approximately three times as potent as atenolol in blocking exercise-induced tachycardia.