U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 3091 - 3100 of 8583 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Ipronidazole is an antiprotozoal drug of the nitroimidazole class used in veterinary medicine. Ipronidazole (2-isopropyl-1-methyl-5-nitroimidazole) is used for the treatment of histomoniasis in turkeys and in swine dysentery.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Xipamide is a diuretic of thiazide class. It is used for the treatment of hypertension and edema. The diuretic effect of the drug is due to reduction of sodium reabsorption and increase in potassium excretion.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Cloforex (Oberex) is an anorectic of the amphetamine class. It is a prodrug to chlorphentermine. It is an appetite-reducing agent, used to treat obesity. The Ministry of Health withdrew preparations containing cloforex as a precautionary measure pending scientific evidence of a relationship between their use and the development of pulmonary hypertension. In Europe Cloforex was approved in 1968 and discontinued in 1969.
Calcium Fumarate is a calcium salt of fumaric acid, it can be used as a food supplement. Calcium Fumarate may be used to treat conditions caused by low Calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure they are getting enough Calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone). Calcium Fumarate is classified by the FDA as a dietary and nutritional additive (21CFR§172.350) and has been used for many years.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



Ronidazole is an antiprotozoal agent. Ronidazole and the other nitroimidazole derivatives damage DNA following reduction of the nitro group. It is used in veterinary for prevention and treatment of various infections including histomoniasis in turkeys, trichomoniasis in pigeons, genital trichomoniasis in cattle, haemorrhagic enteritis in pigs and Tritrichomonas foetus in cats.
Status:
Possibly Marketed Outside US
Source:
Fenafluke by Bryant, C.|Smith, M.J.H.|Williams, J.P.G.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Rafoxanide is a halogenated salicylanilide used as a fasciolicide in cattle, sheep, goats, and horses. It is also active against nematodes, and the sheep nasal bot fly. Rafoxanide acts as by uncoupling oxidative phosphorylation of flukes, including reduced ATP levels, decreased glycogen content and accumulation of succinate.
Status:
Possibly Marketed Outside US
Source:
TINSET by Cession-Fossion, A.|Monard, Y.|Dresse, A.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Oxatomide is a H1-histamine receptor antagonist developed for the treatment of broad spectrum of allergic and other hypersensitivity reactions. The drug is currently marketed in Japan, Taiwan, Italy, Portugal, Indonesia, Argentina, South Africa.
Status:
Possibly Marketed Outside US
Source:
NCT00180102: Phase 4 Interventional Completed Leukemia, Nonlymphocytic, Acute
(2003)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. Although its mechanism of action is incompletely defined, amsacrine inhibits DNA synthesis by binding to and intercalating with DNA. Amsacrine also inhibits topoisomerase II activity and may exert an effect on cell membranes. This agent also possesses immunosuppressive and antiviral properties. While amsacrine is not cell cycle phase-specific, cytotoxicity is maximal during the G2 and S phases.
Pholcodine is an opioid that has been widely used worldwide since 1950 for the treatment of non-productive cough in children and adults. Illicit drug. Additionally Pholcodine is a marker for sensitization to neuromuscular blocking agents (NMBA) and is intended for use as a diagnostic tool in NMBA-induced anaphylaxis.
Status:

Class (Stereo):
CHEMICAL (ACHIRAL)



Meglutol (3-Hydroxy-3-methylglutaric acid, HMGA) is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate-limiting enzyme in the biosynthesis of cholesterol. 3-Hydroxy-3-methylglutaric acid (HMGA) is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCoAR) and strongly reduces cholesterol biosynthesis both in vitro and in vivo. In hamster model HMGA is effective in reducing both bile cholesterol supersaturation and hypercholesterolemia.

Showing 3091 - 3100 of 8583 results