Acemannan, an acetylated polymannose from Aloe vera, has immunomodulatory effects. Acemannan induces IL-6/-8 expression, and p50/DNA binding in gingival fibroblasts, at least partly, via a TLR5/NF-κB-dependent signaling pathway. Acemannan selectively binds with TLR5 ectodomain flagellin recognition sites. Acemannan has various medicinal properties like osteogenic, anti-inflammatory, and antibacterial, which accelerate healing of lesions. Also, acemannan is known to have antiviral and antitumor activities in vivo through activation of immune responses. It was concluded that Aloe vera has immense potential as a therapeutic agent. Acemannan induces tissue repair. Acemannan promoted skin wound healing partly through activating AKT/mTOR-mediated protein translation mechanism, which may represent an alternative therapy approach for cutaneous wound. Many research groups have demonstrated the role of acemannan in dentistry. Acemannan can be used for the treatment of oral aphthous ulceration in patients who wish to avoid the use of steroid medication. Acemannan is an effective natural bioactive substance that promotes bone growth, increases bone surface, bone volume and bone density.