U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 12501 - 12510 of 13362 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)



Tetramisole is a racemic mixture of levamisole and its enantiomer dexamisole, which is a specific inhibitor of tissue non-specific alkaline phosphatase (TNAP). This drug is used in veterinary to treat of ascariasis and other worm infections e.g hook-"ms. And also is used as an immunostimulant (in that case it is used for longer periods of time).
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Targets:


Diflucortolone (used in the form of valerate prodrug) is a corticosteroid developed for the treatment of inflammatory skin diseases. It is supposed that Diflucortolone acts by inducing Annexin A1, a phospholipase A2 inhibitory protein, and thus controls the biosynthesis of prostagladins and leukotrienes. The drug is marketed as a cream under the tradename Nerisone.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ABSOLUTE)

Quingestanol is a metabolite of the quingestanol acetate, oral contraceptive, which was studied for therapy of menopausal diabetic women. Quingestanol is also a prodrug of norethisterone, which is used in birth control.
Magnesite (magnesium carbonate) is a non-toxic mineral. Magnesium carbonate is an effective phosphate binder for chronic hemodialysis patients. It prevents vascular calcification in these patients. Many patients with heavily symptomatic Mitral valve prolapse syndrome have low serum magnesium, and supplementation of this ion by means of magnesium carbonate leads to improvement in most symptoms.
Tetrydamine is a member of the indazol class of non-steroidal anti-inflammatory drugs. It is an analgesic and anti-inflammatory drug. Tetrydamine lavage reduced or eliminated all inflammation symptoms like burning, leucorrhea, etc. and resulted very well tolerated in vulvovaginitis, symptomatic bacterial vaginosis and cervicitis treatment.
Status:
Possibly Marketed Outside US
Source:
NCT00729339: Phase 4 Interventional Completed Gastroesophageal Reflux Disease
(2008)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Mosapride is a gastroprokinetic agent, a 5-HT4 receptor agonist and 5-HT3 receptor antagonist exhibiting no activity at dopamine D2, 5-HT1 and 5-HT2 receptors. Mosapride stimulates serotonin receptor in the digestive tract and increases acetylcholine release to promote upper digestive tract (stomach and duodenum) and lower digestive tract (colon) motility. It is usually used to treat heartburn, nausea and vomiting caused by chronic gastritis. Mosapride is approved and marketed in the countires of Asia and Latin America.
Status:
Possibly Marketed Outside US
Source:
LULLAN by Dainippon Sumitomo Pharma
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Perospirone (Lullan®) is an atypical antipsychotic of the azapirone family. It is used in Japan for the treatment of schizophrenia and acute cases of bipolar mania. Its primary mode of action is through antagonism of serotonin 5-HT2A and dopamine D2 receptors.
Status:
Possibly Marketed Outside US
Source:
Farom by Asubio Pharma
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Faropenem is a unique antimicrobial penem being developed for oral administration. It markets it in two forms: faropenem sodium and faropenem medoxomil. The high binding affinities of faropenem to penicillin-binding proteins from gram-negative and gram-positive bacteria are mirrored by its pronounced and concentration-dependent bactericidal effect. It is usually used to treat a wide range of infections such as skin, respiratory and otorhinologic infections. The most commonly reported adverse reactions include diarrhea, abdominal pain, loose stool, rash and nausea. The FDA refused to approve faropenem – the applicant have to conduct new studies and clinical trials to prove the drug treats community-acquired pneumonia, bacterial sinusitis, chronic bronchitis, and skin infections.
Status:
Possibly Marketed Outside US
Source:
Promintic by Imperial Chemical Industries
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Metyridine has been shown to possess anthelmintic activity, particularly for the nematodes of the alimentary canal. Methyridine is able to pass freely through most of the barriers, which maintain body integrity. It produces neuromuscular block of the decamethonium type. There appears to be sufficient difference between the sensitivity of nematode and vertebrate nervous systems to this drug to allow a wide safety margin for its use in animals. Signs of toxicity, principally dullness and lassitude, may be produced by overdosage of the drug. When given subcutaneously methyridine may cause local pain, and swelling.
Status:
Possibly Marketed Outside US
Source:
Sputolosin by Boehringer Ingelheim
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Dembrexine is a mucolytic agent which reduces the viscosity of respiratory mucus. It improves movement of mucus in small airways. Dembrexine increases secretion of the serous cells in the glands of the nasal, tracheal and bronchial cells and in type II alveolar cells. It also possesses an anti-tussive effect. Dembrexine is used in the treatment of respiratory disease in horses. All respiratory infections with increased secretions. Acute, sub-acute bronchitis. Chronic respiratory disease. Infection of the upper airways.

Showing 12501 - 12510 of 13362 results