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Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
1,3-Dipropylxanthine is an A1 and A2 adenosine receptors inhibitor. It is selective for the A1 receptors. 1,3-Dipropylxanthine was about 2- to 3-fold more potent than theophylline at A2 receptors, while being 5- to 6-fold more potent at A1 receptors.
Norlidocaine (monoethylglycinexylidide, MEGX) is the major metabolite of lidocaine. The lidocaine metabolites formed on the first pass, which include MEGX and GX, have additive central nervous system (CNS) toxicity to lidocaine itself, making oral administration unacceptable. Monoethylglycinexylidide (MEGX) also has local anesthetic activity. It contributes to central nervous system (CNS) toxicity in some patients treated with lidocaine. Lidocaine is eliminated mainly by biotransfomation to monoethylglycinexylidide. MEGX has pharmacologic activity. MEGX has an antiarrhythmic potency of the same order as lidocaine in vitro in a guinea pig atrium model and is about half as potent in vivo in dogs.
MOLYBDATE ION MO-99 is used as a precursos of Tc-99, the last is the most commonly used medical radioisotope. Mo 99 is primarily extracted from U-235 fission products, and then undergoes β decay with a half-life of 66 hours, and the Tc-99 is then chemically extracted. A few micrograms of Mo-99 can produce enough Tc-99 to perform as many as 10,000 tests.
(+)-Narcotine is an epimer of Noscapine
Bicyclomycin benzoate is a benzoate ester of bicyclomycin, an antibiotic. There is a little formal information about biological and pharmacological actions of Bicyclomycin benzoate but it is mentioned that it has limited use as a veterinary antibiotic.
Cupric cyanide represents an amorphous yellow powder insoluble in water. It is used in organic synthesis as the catalyst. Acute copper poisoning after ingestion can cause liver injury, methemoglobinemia, and hemolytic anemia. Acute renal failure may result, secondary to massive hemoglobinuria.
P-Aminoazobenzene (4-Aminoazobenzene) is an intermediate in the production of diazo dyes such as Aniline Yellow, azo dyes and indulines (asphalt additive). The patch test solution of 4-Aminoazobenzene 1% may be used as screener for allergies to azo dyes. P-Aminoazobenzene is a carcinogen.
Status:
Other
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
T-98475 is a non-peptide gonadotropin-releasing hormone receptor antagonist. Upon oral administration, T-98475 was able to suppress suppression of plasma LH concentrations in castrated male cynomolgus monkeys. However, the in vivo antagonism of T-98475 when administered orally was not as effective as was expected, and development of compound was discontinued in favor of more advanced drug candidates.
Z- Azoxybenzene has attracted limited investigational interest. An early stage investigation was conducted on rats to determine the effect of Z-azoxybenzene on liver enzymes. It was found that oral administration of azoxybenzene caused a time and dose-dependent decrease for cytochrome P-450 as well as in the ability of aminopyrine-N-demethylation and aniline hydroxylation. In both male and female rats, there was retardation in body weight gain and increases in relative liver weight, and an increase in the amount of microsomal cytochrome b5.
2,3-Benzofuran is a colorless, sweet-smelling, oily liquid, made by processing coal into coal oil. 2,3-Benzofuran is produced as a component of the crude heavy solvent fraction of the coal-tar light oil formed by the coking of bituminous coal. 2,3-Benzofuran is not isolated for commercial purposes. However, the coumarone-indene resin may be used as a coating on grapefruit, lemons, limes, oranges, tangelos, and tangerines. Coumarone-indene resin is also used in the production of paints and varnishes for corrosion-resistant coatings and water-resistant coatings on paper products and fabrics and as adhesives in food containers. Coumarone-indene resin has been used in asphalt floor tiles.