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Sezary syndrome

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QUISINOSTAT

9BJ85K1J8S

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Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histone deacetylase 10

Histone deacetylase 1

Histone deacetylase 4

Histone deacetylase 2

Histone deacetylase 11

Conditions:

Sezary syndrome

Non-small cell lung cancer

Quisinostat is an orally bioavailable potent histone deacetylase inhibitor, specifically selected due to its sustained inhibition of HDAC1 in solid tumor tissues and prolonged period of half-elimination from tissues. Phase 2 clinical trials are ongoi...

ng in patients with platinum-resistant ovarian cancer and non-small cell lung cancer (NSCLC). Quisinostat is active in the treatment of patients with relapsed or refractory Sézary syndrome. The most common drug-related adverse events reported in this trial were: nausea, diarrhea, asthenia. Grade 3 adverse events were also reported: hypertension, lethargy and pruritus.

QUISINOSTAT HYDROCHLORIDE

WUV1QHM1CS

Export Data
Search for Structure

Status:

Investigational

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Histone deacetylase 10

Histone deacetylase 1

Histone deacetylase 4

Histone deacetylase 2

Histone deacetylase 11

Conditions:

Sezary syndrome

Non-small cell lung cancer

Quisinostat is an orally bioavailable potent histone deacetylase inhibitor, specifically selected due to its sustained inhibition of HDAC1 in solid tumor tissues and prolonged period of half-elimination from tissues. Phase 2 clinical trials are ongoi...

ng in patients with platinum-resistant ovarian cancer and non-small cell lung cancer (NSCLC). Quisinostat is active in the treatment of patients with relapsed or refractory Sézary syndrome. The most common drug-related adverse events reported in this trial were: nausea, diarrhea, asthenia. Grade 3 adverse events were also reported: hypertension, lethargy and pruritus.

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