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Diabetic wound healing

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Unknown

2,578

Pain

614

Cancer

592

Hypertension

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PI3K-Akt signaling pathway

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Kunimine, S.|Suzuki, S.

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DEHYDROABIETIC ACID

0S5XP6S3AU

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Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

TGF-beta signaling pathway

PI3K-Akt signaling pathway

Conditions:

Metabolic syndrome

Diabetic wound healing

Dehydroabietic acid (DHA or DAA), a diterpene, is obtained from Commiphora oppbalsamum. DHA has potential as treatment for obesity and metabolic syndrome, obese diabetic KK-Ay mice treated with DHA showed decreased plasma glucose, insulin, and trigly...

ceride levels. It has been reported that DHA inhibits the production of proinfammatory mediators such as TNF-α in macrophages and adipocytes and causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Also was shown, that DHA could reverse several cell responses stimulated by TNF-α, including the activation of FOXO1 and the TGF-β1/Smad3 signaling pathway. Thus, DAA could be useful in improving the diabetic wound healing.

SODIUM DEHYDROABIETATE

MCO4K53W9N

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Search for Structure

Status:

Other

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

TGF-beta signaling pathway

PI3K-Akt signaling pathway

Conditions:

Metabolic syndrome

Diabetic wound healing

Dehydroabietic acid (DHA or DAA), a diterpene, is obtained from Commiphora oppbalsamum. DHA has potential as treatment for obesity and metabolic syndrome, obese diabetic KK-Ay mice treated with DHA showed decreased plasma glucose, insulin, and trigly...

ceride levels. It has been reported that DHA inhibits the production of proinfammatory mediators such as TNF-α in macrophages and adipocytes and causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Also was shown, that DHA could reverse several cell responses stimulated by TNF-α, including the activation of FOXO1 and the TGF-β1/Smad3 signaling pathway. Thus, DAA could be useful in improving the diabetic wound healing.

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