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Calf diphtheria

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SULFADIMETHOXINE

30CPC5LDEX

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Status:

US Previously Marketed

First approved in 1958

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Folate biosynthesis

Conditions:

Calf diphtheria

Pneumonia associated with Pasteurella Spp.

Sulfadimethoxine is a sulfonamide antibacterial used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some c...

ountries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. Sulfadimethoxine is approved in Russia for use in humans, including children, and has been successfully used there for more than 35 years and is available as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies. In USA and Europe sulfadimethoxine is approved in a veterinary medicinal products. ANADA was approved by FDA in US in 1997 as an Over the Counter medicine for treatment of bovine respiratory disease complex (shipping fever complex) and bacterial pneumonia associated with Pasteurella Spp. Sensitive to sulfadimethoxine; necrotic pododermatitis (foot rot) and calf diphtheria caused by Fusobacterium necrophorum (Sphaerophorus necrophorus) sensitive to sulfadimethoxine. Bioequivalence for this generic animal drug, Sulfadimethoxine Injection 40%, was established by demonstration of chemical equivalence to the pioneer product, Hoffmann-La Roche's Albon® Injection 40% (NADA 041-245).

TYLOSIN

YEF4JXN031

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Status:

Possibly Marketed Outside US

First approved in 2009

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Fusobacterium necrophorum growth

Pasteurella multocida growth

Mycoplasma sp. 1220 growth

Streptococcus pneumoniae growth

Staphylococcus aureus growth

Conditions:

Calf diphtheria

Bovine respiratory complex

Tylosin (trade names Tylocine, Tylan) is a bacteriostat feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. It is found naturally as a fermenta...

tion product of Streptomyces fradiae. It is a macrolide antibiotic. Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. Tylosin is certified by the FDA but is only approved for use in livestock such as cattle, chickens, swine, and turkeys. The FDA has prohibited the use of tylosin in dogs and cats, except where it is specifically prescribed by a veterinarian. Tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.

SULFADIMETHOXINE SODIUM

49DG2B481W

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Status:

US Previously Marketed

First approved in 1958

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Folate biosynthesis

Conditions:

Calf diphtheria

Pneumonia associated with Pasteurella Spp.

Sulfadimethoxine is a sulfonamide antibacterial used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections. It is most frequently used in veterinary medicine, although it is approved in some c...

ountries for use in humans. Sulfadimethoxine inhibits bacterial synthesis of folic acid (pteroylglutamic acid) from para-aminobenzoic acid. Sulfadimethoxine is approved in Russia for use in humans, including children, and has been successfully used there for more than 35 years and is available as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies. In USA and Europe sulfadimethoxine is approved in a veterinary medicinal products. ANADA was approved by FDA in US in 1997 as an Over the Counter medicine for treatment of bovine respiratory disease complex (shipping fever complex) and bacterial pneumonia associated with Pasteurella Spp. Sensitive to sulfadimethoxine; necrotic pododermatitis (foot rot) and calf diphtheria caused by Fusobacterium necrophorum (Sphaerophorus necrophorus) sensitive to sulfadimethoxine. Bioequivalence for this generic animal drug, Sulfadimethoxine Injection 40%, was established by demonstration of chemical equivalence to the pioneer product, Hoffmann-La Roche's Albon® Injection 40% (NADA 041-245).

TYLOSIN HYDROCHLORIDE

J606ECM5R3

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Status:

Possibly Marketed Outside US

First approved in 2009

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Fusobacterium necrophorum growth

Pasteurella multocida growth

Mycoplasma sp. 1220 growth

Streptococcus pneumoniae growth

Staphylococcus aureus growth

Conditions:

Calf diphtheria

Bovine respiratory complex

Tylosin (trade names Tylocine, Tylan) is a bacteriostat feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. It is found naturally as a fermenta...

tion product of Streptomyces fradiae. It is a macrolide antibiotic. Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. Tylosin is certified by the FDA but is only approved for use in livestock such as cattle, chickens, swine, and turkeys. The FDA has prohibited the use of tylosin in dogs and cats, except where it is specifically prescribed by a veterinarian. Tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.

TYLOSIN PHOSPHATE

NR75X12AFF

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Status:

Possibly Marketed Outside US

First approved in 2009

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Fusobacterium necrophorum growth

Pasteurella multocida growth

Mycoplasma sp. 1220 growth

Streptococcus pneumoniae growth

Staphylococcus aureus growth

Conditions:

Calf diphtheria

Bovine respiratory complex

Tylosin (trade names Tylocine, Tylan) is a bacteriostat feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. It is found naturally as a fermenta...

tion product of Streptomyces fradiae. It is a macrolide antibiotic. Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. Tylosin is certified by the FDA but is only approved for use in livestock such as cattle, chickens, swine, and turkeys. The FDA has prohibited the use of tylosin in dogs and cats, except where it is specifically prescribed by a veterinarian. Tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.

TYLOSIN TARTRATE

5P4625C51T

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Status:

Possibly Marketed Outside US

First approved in 2009

Class (Stereo):

CHEMICAL (ABSOLUTE)

Targets:

Fusobacterium necrophorum growth

Pasteurella multocida growth

Mycoplasma sp. 1220 growth

Streptococcus pneumoniae growth

Staphylococcus aureus growth

Conditions:

Calf diphtheria

Bovine respiratory complex

Tylosin (trade names Tylocine, Tylan) is a bacteriostat feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. It is found naturally as a fermenta...

tion product of Streptomyces fradiae. It is a macrolide antibiotic. Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. Tylosin is certified by the FDA but is only approved for use in livestock such as cattle, chickens, swine, and turkeys. The FDA has prohibited the use of tylosin in dogs and cats, except where it is specifically prescribed by a veterinarian. Tylosin has a bacteriostatic effect on susceptible organisms, caused by inhibition of protein synthesis through binding to the 50S subunit of the bacterial ribosome.

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