U.S. Department of Health & Human Services
National Institutes of Health
NCATS
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CNS Activity
CNS Active
4,002
CNS Penetrant
2,588
CNS Non-penetrant
1,040
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Development Status
US Approved Rx
1,143
Possibly Marketed Outside US
897
Investigational
685
Other
633
US Previously Marketed
463
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Primary Target
Dopamine D2 receptor
200
Histamine H1 receptor
171
Mu opioid receptor
163
GABA-A receptor; anion channel
138
Serotonin 2a (5-HT2a) receptor
126
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Highest Phase
Approved
2,207
Phase II
264
Phase III
179
Not Provided
97
Phase I
89
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Approval Year
Unknown
2,027
1921
212
1959
61
1955
47
1961
44
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Condition
Unknown
360
Pain
320
Anxiety
237
Schizophrenia
227
Alzheimer’s disease
191
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Treatment Modality
Primary
2,959
Palliative
409
Preventing
369
Curative
226
Secondary
107
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Originator
Pfizer
105
Merck
92
Hoffman-La Roche
65
Eli Lilly
61
GlaxoSmithKline
52
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Substance Class
Chemical
3,960
Mixture
20
Protein
18
Polymer
2
Group 1 Specified Substance
1
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INN Stem
Chemical substance(-ine)
6
Beta-blockers(-olol)
1
Tyrosine-kinase inhibitors(-tinib)
1
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Code System
FDA UNII
4,002
CAS
3,937
PUBCHEM
3,829
EPA CompTox
3,204
SMS_ID
2,527
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Protein Type
PEPTIDE
3
HORMONE
2
TOXIN
1
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ATC Level 1
NERVOUS SYSTEM
323
ALIMENTARY TRACT AND METABOLISM
82
CARDIOVASCULAR SYSTEM
73
RESPIRATORY SYSTEM
65
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
38
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ATC Level 2
PSYCHOLEPTICS
108
PSYCHOANALEPTICS
75
ANALGESICS
43
ANTIEPILEPTICS
31
OPHTHALMOLOGICALS
30
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ATC Level 3
ANTIPSYCHOTICS
50
ANTIDEPRESSANTS
48
HYPNOTICS AND SEDATIVES
37
ANTIEPILEPTICS
31
OPIOIDS
24
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ATC Level 4
Benzodiazepine derivatives
28
Other antidepressants
19
Non-selective monoamine reuptake inhibitors
15
Centrally acting antiobesity products
12
Protein kinase inhibitors
12
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Substance Form
Salts, Hydrates, Esters, etc.
2,095
Principal Form
1,907
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CNS Activity
CNS Active
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