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N-ethylmaleimide (NEM), a sulfhydryl reagent, functions as an oxidizing agent in biological and non-biological systems. It behaves as an oxidizing agent with an interacting site in the region QH2-cytochrome A of the respiratory chain. In addition was identified, that NEM can be a potential antidote against As2 O3 -mediated DNA damage in a glutathione-dependent manner.