U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 21 - 30 of 495 results

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)



GALLIPRANT® (grapiprant tablets) is a prostaglandin E2 (PGE2) EP4 receptor antagonist; a non-cyclooxygenase (COX) inhibiting, non-steroidal antiinflammatory drug (NSAID) in the piprant class. Grapiprant is indicated for the control of pain and inflammation associated with osteoarthritis in dogs. It is approved for veterinary use, but it is in phase II development in Japan for the treatment of chronic inflammatory pain, including osteoarthritis and rheumatoid arthritis. Grapiprant shows similar in vitro binding affinity (Ki) for the rat and dog EP4 receptor, 20 and 24 nM, respectively.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Targets:

Conditions:

Egtazic acid or EGTA is widely used for biological research as a chelating agent relatively more specific for calcium ions.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (MIXED)

Solasulfone (sulphetrone) was used in drug therapy of leprosy. It was also used in a chemotherapy of pulmonary tuberculosis. Sulphetrone has a low toxicity and an antituberculous efficiency approaching that of its parent compound, diaminodiphenylsulphone; it is also curative in infections due to beta-haemolytic streptococci.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)