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1911

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1921

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Muscarinic acetylcholine receptor

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Sodium channel protein type II alpha subunit

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Belladonna alkaloids, semisynthetic, quaternary ammonium compounds

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Showing 1 - 5 of 5 results

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METHYLATROPINIUM

80719I460H

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic acetylcholine receptor

Conditions:

Pyloric stenosis

Pyloric stenosis

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...

o its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

CHLOROBUTANOL

HM4YQM8WRC

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type II alpha subunit

Conditions:

Chlorobutanol, or trichloro-2-methyl-2-propanol, is an analgesic and sedative hypnotic in man, and an experimental general anesthetic. It has antibacterial and antifungal properties. It is also used chemical preservative for parenteral drugs. It was ...

found, that chlorobutanol inhibited mammalian Nav 1.2 channels at concentrations less than those used to preserve parenteral solutions. Its mechanism of inhibiting Na channels differs from that of local anesthetics in that it does not show use dependent or state dependent inhibition.

METHYLATROPINE BROMIDE

63IFT0IX9N

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic acetylcholine receptor

Conditions:

Pyloric stenosis

Pyloric stenosis

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...

o its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

CHLOROBUTANOL HEMIHYDRATE

3X4P6271OX

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel protein type II alpha subunit

Conditions:

Chlorobutanol, or trichloro-2-methyl-2-propanol, is an analgesic and sedative hypnotic in man, and an experimental general anesthetic. It has antibacterial and antifungal properties. It is also used chemical preservative for parenteral drugs. It was ...

found, that chlorobutanol inhibited mammalian Nav 1.2 channels at concentrations less than those used to preserve parenteral solutions. Its mechanism of inhibiting Na channels differs from that of local anesthetics in that it does not show use dependent or state dependent inhibition.

METHYLATROPINE NITRATE

Q48D9J47K2

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Status:

US Previously Marketed

First marketed in 1911

Class (Stereo):

CHEMICAL (EPIMERIC)

Targets:

Muscarinic acetylcholine receptor

Conditions:

Pyloric stenosis

Pyloric stenosis

Methylatropine (methylatroponium) is a belladonna derivative. In 1902 the Bayer Company introduced atropine methonitrate, a quaternary ammonium salt of atropine (Eumydrin), as a mydriatic for dilation of the pupil during ophthalmic examination. Due t...

o its highly polar nature it penetrates less readily into the central nervous system than atropine and was therefore introduced for relieving pyloric spasms in infants. Atropine methyl nitrate is a muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier. Atropine methyl nitrate has been used for its peripheral muscarinic effects (targeting the bladder, respiratory tract, and to block parasympathetic signaling to the heart, among others) and to separate central from peripheral nervous system effects, or to protect against peripheral side effects when using muscarinics that do cross the blood brain barrier.

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