Inxight Drugs

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Approval Year

1907

6

Unknown

149,123

1921

1,468

2024

711

2020

691

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US Previously Marketed

6

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Primary Target

Sodium channel alpha subunit

3

Voltage-gated calcium channel

2

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Approved

2

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Pain

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Primary

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Originator

Sandoz, M.

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Fourneau, E.

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Chemical

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CAS

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EPA CompTox

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Showing 1 - 6 of 6 results

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TRICAINE

02591PHL19

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Status:

US Previously Marketed

First marketed in 1907

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel alpha subunit

Conditions:

Tricaine (MS-222, Tricaine-S), a water-soluble local anesthetic, is used commonly for sedation, immobilization, and anesthesia of poikilothermic animals and has been accepted as a common anesthetic for use in the cold-blooded animals. It has long bee...

n recognized as a valuable tool for the proper handling of these animals during manual spawning (fish stripping), weighing, measuring, marking, surgical operations, transport, photography, and research. Tricaine was developed by Merck as a sulfonated analog of benzocaine with high solubility in water. The main advantage of Tricaine is the short duration of action and rapid metabolism. There are many reports describing the use of Tricaine for anesthetizing poikilothermic animals because it is a safe agent for immersion anesthesia even though the other anesthetics such as ether, ethanol, thiopental, halothane, isoflurane, barbiturates also could be used. Amphibians could be anesthetized easily by immersion methods with Tricaine because the amphibian skin is extremely permeable and water is absorbed through the skin rather than ingested. Tricaine has been administered as an injectable agent also.

AMYLOCAINE

QRW683O56T

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Status:

US Previously Marketed

First marketed in 1907

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Voltage-gated calcium channel

Conditions:

Amylocaine (trade name Stovaine) is a local anesthetic, that was widely used for spinal anesthesia in Caesarean section. The dose used would produce anesthesia for up to 1 h. Reports of the use of spinal analgesia for abdominal and perineal surgery i...

n infants are found from several centers during the first half of the twentieth century. However, this agent often fails to provide good maternal sensory block and currently, Amylocaine has been replaced with new anesthetics.

CEROUS SALICYLATE

0001H6R5H1

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Status:

US Previously Marketed

First marketed in 1907

Class (Stereo):

CHEMICAL (ACHIRAL)

TRICAINE HYDROCHLORIDE

YN380NNA9P

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Search for Structure

Status:

US Previously Marketed

First marketed in 1907

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel alpha subunit

Conditions:

Tricaine (MS-222, Tricaine-S), a water-soluble local anesthetic, is used commonly for sedation, immobilization, and anesthesia of poikilothermic animals and has been accepted as a common anesthetic for use in the cold-blooded animals. It has long bee...

n recognized as a valuable tool for the proper handling of these animals during manual spawning (fish stripping), weighing, measuring, marking, surgical operations, transport, photography, and research. Tricaine was developed by Merck as a sulfonated analog of benzocaine with high solubility in water. The main advantage of Tricaine is the short duration of action and rapid metabolism. There are many reports describing the use of Tricaine for anesthetizing poikilothermic animals because it is a safe agent for immersion anesthesia even though the other anesthetics such as ether, ethanol, thiopental, halothane, isoflurane, barbiturates also could be used. Amphibians could be anesthetized easily by immersion methods with Tricaine because the amphibian skin is extremely permeable and water is absorbed through the skin rather than ingested. Tricaine has been administered as an injectable agent also.

TRICAINE METHANESULFONATE

971ZM8IPK1

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Status:

US Previously Marketed

First marketed in 1907

Class (Stereo):

CHEMICAL (ACHIRAL)

Targets:

Sodium channel alpha subunit

Conditions:

Tricaine (MS-222, Tricaine-S), a water-soluble local anesthetic, is used commonly for sedation, immobilization, and anesthesia of poikilothermic animals and has been accepted as a common anesthetic for use in the cold-blooded animals. It has long bee...

n recognized as a valuable tool for the proper handling of these animals during manual spawning (fish stripping), weighing, measuring, marking, surgical operations, transport, photography, and research. Tricaine was developed by Merck as a sulfonated analog of benzocaine with high solubility in water. The main advantage of Tricaine is the short duration of action and rapid metabolism. There are many reports describing the use of Tricaine for anesthetizing poikilothermic animals because it is a safe agent for immersion anesthesia even though the other anesthetics such as ether, ethanol, thiopental, halothane, isoflurane, barbiturates also could be used. Amphibians could be anesthetized easily by immersion methods with Tricaine because the amphibian skin is extremely permeable and water is absorbed through the skin rather than ingested. Tricaine has been administered as an injectable agent also.

AMYLOCAINE HYDROCHLORIDE

224EF0K14Q

Export Data
Search for Structure

Status:

US Previously Marketed

First marketed in 1907

Class (Stereo):

CHEMICAL (RACEMIC)

Targets:

Voltage-gated calcium channel

Conditions:

Amylocaine (trade name Stovaine) is a local anesthetic, that was widely used for spinal anesthesia in Caesarean section. The dose used would produce anesthesia for up to 1 h. Reports of the use of spinal analgesia for abdominal and perineal surgery i...

n infants are found from several centers during the first half of the twentieth century. However, this agent often fails to provide good maternal sensory block and currently, Amylocaine has been replaced with new anesthetics.

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