Puxitatug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:24:06 GMT 2025` Edited by `admin` on `Wed Apr 02 13:24:06 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	ZZ6R8M49EG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Puxitatug

Official Name

English

INT-016

Preferred Name

English

PUXITATUG [USAN]

Common Name

English

puxitatug [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens VTCN1(V-set domain containing T cell activation inhibitor 1, B7 family member H4, B7H4, B7-H4)], Homo sapiens monoclonal antibody; (gamma1 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV4-34*01 (95.9%)

Common Name

English

Immunoglobulin G1, anti-(human B7 homolog 4 protein) (human monoclonal INT-016 ?1-chain), disulfide with human monoclonal INT-016 ?-chain, dimer

Common Name

English

Code System Code Type Description

INN

12514

Created by admin on Wed Apr 02 13:24:06 GMT 2025 , Edited by admin on Wed Apr 02 13:24:06 GMT 2025

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USAN

MN-79

Created by admin on Wed Apr 02 13:24:06 GMT 2025 , Edited by admin on Wed Apr 02 13:24:06 GMT 2025

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SMS_ID

300000048712

Created by admin on Wed Apr 02 13:24:06 GMT 2025 , Edited by admin on Wed Apr 02 13:24:06 GMT 2025

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CAS

2760250-47-1

Created by admin on Wed Apr 02 13:24:06 GMT 2025 , Edited by admin on Wed Apr 02 13:24:06 GMT 2025

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FDA UNII

ZZ6R8M49EG

Created by admin on Wed Apr 02 13:24:06 GMT 2025 , Edited by admin on Wed Apr 02 13:24:06 GMT 2025

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NCI_THESAURUS

C199014

Created by admin on Wed Apr 02 13:24:06 GMT 2025 , Edited by admin on Wed Apr 02 13:24:06 GMT 2025

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From	To
1_22	1_95
2_22	2_95
2_144	2_200
2_220	4_214
2_261	2_321
1_144	1_200
2_367	2_425
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_220	3_214
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_52
N	1_297
N	2_52
N	2_297

Related Record Type Details


					396QL65J3Q

Puxitatug Samrotecan

CONJUGATE -> PARENT

Amount:


					CSK3SHL2SF

V-SET DOMAIN-CONTAINING T-CELL ACTIVATION INHIBITOR 1

TARGET->LIGAND

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_447] [2_447]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION				Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL