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Details

Stereochemistry ACHIRAL
Molecular Formula C12H24O2.C2H6NO3S.Na
Molecular Weight 347.4481
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM TAURINE LAURATE

SMILES

CCCCCCCCCCCC(=O)[O-].C(CS(=O)(=O)O)N.[Na+]

InChI

InChIKey=HLGSTHXLGGPEDB-UHFFFAOYSA-M
InChI=1S/C12H24O2.C2H7NO3S.Na/c1-2-3-4-5-6-7-8-9-10-11-12(13)14;3-1-2-7(4,5)6;/h2-11H2,1H3,(H,13,14);1-3H2,(H,4,5,6);/q;;+1/p-1

HIDE SMILES / InChI

Molecular Formula C2H6NO3S
Molecular Weight 124.1401
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C12H24O2
Molecular Weight 200.3182
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3676193 | http://www.medscape.com/viewarticle/804080 | https://www.ncbi.nlm.nih.gov/pubmed/21334852 | https://www.ncbi.nlm.nih.gov/pubmed/26208967

Taurine is a semi-essential amino acid and is not incorporated into proteins. Taurine is considered conditionally essential because it cannot be synthesized by infants younger than 4-6 weeks, and it may not be adequately synthesized in patients receiving long-term parenteral nutrition and patients with short-term hypermetabolic conditions. In mammalian tissues, taurine is ubiquitous and is the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes. Taurin occurs naturally in fish and meat. The mean daily intake from omnivore diets was determined to be around 58 mg. Taurine is a component of energy drinks, with many contain 1000 mg per serving. In medicine, taurine supplementation demonstrated efficacy in relieving symptoms of heart failure, hepatitis, hypertension and psychotic disorder. Taurine exerts many physiological functions, including membrane stabilization, osmoregulation and cytoprotective effects, antioxidant and anti-inflammatory actions as well as modulation of intracellular calcium concentration and ion channel function. In addition taurine may control muscle metabolism and gene expression, through yet unclear mechanisms. The cellular and biochemical mechanisms mediating the actions of taurine are not fully known.

Originator

Curator's Comment:: Taurin was first isolated from ox bile in 1827.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
406.0 µM [EC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
TAURINE

Approved Use

Taking 2-3 grams of taurine by mouth one to two times daily for 6-8 weeks seems to improve heart function and symptoms in patients with moderate heart failure to severe heart failure. Some patients with severe heart failure rapidly improve from NYHA class IV to II after 4-8 weeks of treatment. Improvement seems to continue for as long as taurine treatment is continued, up to one year.
Palliative
TAURINE

Approved Use

Taking 1.5-4 grams of taurine daily for up to 3 months improves liver function in people with hepatitis.
Preventing
URSA Complex

Approved Use

Taurine is a component of energy drinks used for relieving of fatigue
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Glutamate and taurine are increased in ventricular cerebrospinal fluid of severely brain-injured patients.
1999 Feb
Sodium nitroprusside-induced seizure and taurine release from rat hippocampus.
2000
The involvement of caspases in the CD95(Fas/Apo-1)- but not swelling-induced cellular taurine release from Jurkat T-lymphocytes.
2000 May
The influence of a taurine containing drink on cardiac parameters before and after exercise measured by echocardiography.
2001
Isolation and characterization of an alpha 2-type zebrafish glycine receptor subunit.
2001
Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype.
2001
New developments in the pharmacotherapy of alcohol dependence.
2001
Oxygen metabolites in immune- stimulated ion transport in rat colon: modulation by taurine.
2001
Two years' experience with Dialock and CLS (a new antimicrobial lock solution).
2001
Zinc and the eye.
2001 Apr
Increased taurine content in esophageal mucosa of children affected by gastroesophageal reflux.
2001 Apr
Conditioned nutritional deficiencies in the cardiomyopathic hamster heart.
2001 Apr
Killing of Schistosoma mansoni sporocysts by hemocytes from resistant Biomphalaria glabrata: role of reactive oxygen species.
2001 Apr
Cellular uptake of taurine by lactating porcine mammary tissue.
2001 Apr
Transport of L-carnitine in isolated cerebral cortex neurons.
2001 Apr
Analysis of amino acids in human serum by isocratic reversed-phase high-performance liquid chromatography with electrochemical detection.
2001 Apr 13
Endogenous glutamate-taurine interaction in striatum and nucleus accumbens of the freely moving rat: studies during the normal process of aging.
2001 Apr 15
Mast cell numbers in the young rat thalamus: a search for control factors.
2001 Aug
Taurine increases rat survival and reduces striatal damage caused by 3-nitropropionic acid.
2001 Aug
Energy-related metabolites during and after induced myocardial infarction with special emphasis on the reperfusion injury after extracorporeal circulation.
2001 Feb
Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.
2001 Feb
Taurine - monograph.
2001 Feb
Hamster sperm glycine receptor: evidence for its presence and involvement in the acrosome reaction.
2001 Feb
Can this pill stop you from hitting the bottle?
2001 Feb 12
The protective effect of taurine against thioacetamide hepatotoxicity of rats.
2001 Jan
Taurine and osmoregulation: platelet taurine content, uptake, and release in type 2 diabetic patients.
2001 Jan
MR diffusion imaging and 1H spectroscopy in a child with medulloblastoma. A case report.
2001 Jan
Taurine modulates catalase, aldehyde dehydrogenase, and ethanol elimination rates in rat brain.
2001 Jan-Feb
The effect of taurine depletion by beta-alanine treatment on the susceptibility to ethanol-induced hepatic dysfunction in rats.
2001 Jan-Feb
Enhanced fungicidal activity of N-chlorotaurine in nasal secretion.
2001 Jun
Occupational lead exposure and amino acid profiles and liver function tests in industrial workers.
2001 Jun
17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids.
2001 Jun
Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells.
2001 Jun 1
Effects of acamprosate on ethanol-seeking and self-administration in the rat.
2001 Mar
A new model for diffuse brain injury by rotational acceleration: II. Effects on extracellular glutamate, intracranial pressure, and neuronal apoptosis.
2001 Mar
Two-voxel localization sequence for in vivo two-dimensional homonuclear correlation spectroscopy.
2001 Mar
Effect of starvation on free histidine and amino acids in white muscle of milkfish Chanos chanos.
2001 Mar
Changes in apparent diffusion coefficients of metabolites in rat brain after middle cerebral artery occlusion measured by proton magnetic resonance spectroscopy.
2001 Mar
Effects of tumor necrosis factor alpha on taurine uptake in cultured rat astrocytes.
2001 Mar
Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials.
2001 May
The influence of plasma on the disinfecting activity of the new antimicrobial agent N-chlorotaurine-sodium in comparison with chloramine T.
2001 May
N-chlorotaurine, a novel endogenous antimicrobial agent: tolerability testing in a mouse model.
2001 May
Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine.
2001 May
Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes.
2001 May
Patents

Sample Use Guides

Taurin occurs naturally in fish and meat. The mean daily intake from omnivore diets was determined to be around 58 mg.
Route of Administration: Oral
In Vitro Use Guide
Agonist properties of taurine on glycine receptor of supraoptic magnocellular neurones acutely dissociated from adult rats, using whole-cell voltage clamp. Responses to 1 mM taurine were blocked by strychnine but not by gabazine and showed no additivity with glycine-induced currents, indicating selective activation of glycine receptors.
Substance Class Chemical
Created
by admin
on Fri Jun 25 20:40:54 UTC 2021
Edited
by admin
on Fri Jun 25 20:40:54 UTC 2021
Record UNII
ZYS0US400F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM TAURINE LAURATE
INCI  
INCI  
Official Name English
DODECANOIC ACID, COMPD. WITH 2-AMINOETHANESULFONIC ACID MONOSODIUM SALT (1:1)
Common Name English
ETHANESULFONIC ACID, 2-AMINO-, COMPD. WITH DODECANOIC ACID, SODIUM SALT (1:1:1)
Common Name English
SODIUM TAURINE LAURATE [INCI]
Common Name English
DODECANOIC ACID, 2-AMINOETHANESULFONIC, SODIUM SALT
Common Name English
ETHANESULFONIC ACID, 2-AMINO-, MONOSODIUM SALT, DODECANOATE
Common Name English
Code System Code Type Description
FDA UNII
ZYS0US400F
Created by admin on Fri Jun 25 20:40:54 UTC 2021 , Edited by admin on Fri Jun 25 20:40:54 UTC 2021
PRIMARY
EPA CompTox
192750-09-7
Created by admin on Fri Jun 25 20:40:54 UTC 2021 , Edited by admin on Fri Jun 25 20:40:54 UTC 2021
PRIMARY
RXCUI
2399553
Created by admin on Fri Jun 25 20:40:54 UTC 2021 , Edited by admin on Fri Jun 25 20:40:54 UTC 2021
PRIMARY
CAS
192750-09-7
Created by admin on Fri Jun 25 20:40:54 UTC 2021 , Edited by admin on Fri Jun 25 20:40:54 UTC 2021
PRIMARY
PUBCHEM
23668864
Created by admin on Fri Jun 25 20:40:54 UTC 2021 , Edited by admin on Fri Jun 25 20:40:54 UTC 2021
PRIMARY
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ACTIVE MOIETY