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Description

Pegamotecan, a pegylated-camptothecin, is a topoisomerase-I inhibitor with a prolonged circulating half-life, tolerability, and passive tumor accumulation. Enzon Pharmaceutical used pegamotecan in trials for the treatment of cancer of the stomach, sarcoma, soft tissue, and gastroesophageal cancer. However, in 2005 Enzon Pharmaceuticals announced that it had discontinued further development of that drug. The Company's decision was based on an interim analysis of the data from a Phase 2b trial in patients with gastric or gastroesophageal cancers. Based on a strategic analysis of the potential investment return versus the required resource allocation and associated development risks, the Company decided not to pursue other potential indications for pegamotecan.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
Camptothecin delivery systems: enhanced efficacy and tumor accumulation of camptothecin following its conjugation to polyethylene glycol via a glycine linker.
1998
A phase II study of pegylated-camptothecin (pegamotecan) in the treatment of locally advanced and metastatic gastric and gastro-oesophageal junction adenocarcinoma.
2009 Jan

Sample Use Guides

In Vivo Use Guide
treated with 7,000 mg/m(2) of pegamotecan as a 1-h infusion every 21 days until disease progression or unacceptable toxicity
Route of Administration: Intravenous
Substance Class Polymer
Created
by admin
on Sat Dec 16 10:16:45 GMT 2023
Edited
by admin
on Sat Dec 16 10:16:45 GMT 2023
Record UNII
ZY7ZTE7LFH
Record Status Validated (UNII)
Record Version
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Name Type Language
PEGAMOTECAN
INN   USAN  
USAN   INN  
Official Name English
PEG-CAMPTOTHECIN
Common Name English
EZ-246
Code English
L-ALANINE, (4S)-4-ETHYL-3,4,12,14-TETRAHYDRO-3,14-DIOXO-1H-PYRANO(3',4':6,7)INDOLIZINO (1,2-B)QUINOLIN-4-YL ESTER, MONO(TRIFLUOROACETATE), REACTION PRODUCTS WITH POLYETHYLENE GLYCOL BIS (CARBOXYMETHYL) ETHER
Common Name English
PROTHECAN
Brand Name English
PEGAMOTECAN [USAN]
Common Name English
pegamotecan [INN]
Common Name English
Code System Code Type Description
ChEMBL
CHEMBL2104977
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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FDA UNII
ZY7ZTE7LFH
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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SMS_ID
300000034263
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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USAN
PP-81
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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INN
8508
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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CAS
581079-18-7
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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NCI_THESAURUS
C174957
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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DRUG BANK
DB12842
Created by admin on Sat Dec 16 10:16:45 GMT 2023 , Edited by admin on Sat Dec 16 10:16:45 GMT 2023
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Display Structure of PEGAMOTECAN
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
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