Details
Stereochemistry | ACHIRAL |
Molecular Formula | C13H24N2O |
Molecular Weight | 224.3425 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C(NC1CCCCC1)NC2CCCCC2
InChI
InChIKey=ADFXKUOMJKEIND-UHFFFAOYSA-N
InChI=1S/C13H24N2O/c16-13(14-11-7-3-1-4-8-11)15-12-9-5-2-6-10-12/h11-12H,1-10H2,(H2,14,15,16)
Molecular Formula | C13H24N2O |
Molecular Weight | 224.3425 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/18312493Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24685540 | https://www.ncbi.nlm.nih.gov/pubmed/22489687
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18312493
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/24685540 | https://www.ncbi.nlm.nih.gov/pubmed/22489687
1,3-Dicyclohexylurea (DCU) is a potent endogenous inhibitor of soluble epoxide hydrolase (sEH), that has been found in human serum. Soluble epoxide hydrolase has been implicated in cardiovascular disease and inflammation in mammals. Endogenously produced 1,3-dicyclohexylurea may have physiological significance via regulation of soluble epoxide hydrolase activity in vivo.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2409 Sources: https://www.ncbi.nlm.nih.gov/pubmed/24685540 |
3.0 nM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high-performance liquid chromatography with electrospray tandem mass spectrometry. | 2001 Dec 15 |
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Impurity profile study of repaglinide. | 2003 Jul 14 |
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Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. | 2004 Dec |
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Role of EETs in regulation of endothelial permeability in rat lung. | 2004 Feb |
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Investigation of the active constituents of Portulaca oleraceae L. (Portulacaceae) growing in Jordan. | 2004 Jan |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18312493
From day 10 to day 14, rats were dosed orally with vehicle or 1,3-Dicyclohexylu at 30 mg/kg twice daily
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24685540
Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxyran-2-yl)methyl] carbonate (CMNPC) is the substrate used for the fluorescent assay. The assay was carried out using a 96 well-plate format. There was a lane for background with PB buffer (100 mM sodium phosphate, pH = 7.4, 200 µL) and two lanes for positive control. Each inhibitor IC50¬ was determined based on triplicate experiments. Each inhibitor (the highest desired concentration, 2 µL, DMSO) was added to the PB buffer (100 mM sodium phosphate, pH = 7.4, 150 µL) at the first set of wells. A series of 2-fold dilution was applied from the first set till to the last set of wells. hSEH solution (25 nM, 100 mM sodium phosphate, pH = 7.4, 20 µL) was added and mixed for 30s. The inhibitor-enzyme mixtures were mixed and incubated at 30 ˚C for 5 min. CMNPC solution (33 µM, 100 mM sodium phosphate, pH = 7.4, 30 µL) was added and mixed. The enzyme activity was measured based on the fluorescence increase.
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 22:45:26 UTC 2022
by
admin
on
Fri Dec 16 22:45:26 UTC 2022
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Record UNII |
ZV7823VVIM
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Record Status |
Validated (UNII)
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Record Version |
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DTXSID3062366
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Dicyclohexylurea
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ZV7823VVIM
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CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
No more than one such impurity (carmustine related compound A, lomustine related compound B, or lomustine related compound C) is greater than 0.2%.
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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