Details
| Stereochemistry | UNKNOWN |
| Molecular Formula | C28H38N4O6 |
| Molecular Weight | 526.6245 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC(=O)C1=C(C)NC(C)=C(C1C2=CC(=CC=C2)[N+]([O-])=O)C(=O)OCC(C)(C)CN3CCN(CC=C)CC3
InChI
InChIKey=QBTSPDQKRVMTRU-UHFFFAOYSA-N
InChI=1S/C28H38N4O6/c1-7-11-30-12-14-31(15-13-30)17-28(4,5)18-38-27(34)24-20(3)29-19(2)23(26(33)37-6)25(24)21-9-8-10-22(16-21)32(35)36/h7-10,16,25,29H,1,11-15,17-18H2,2-6H3
| Molecular Formula | C28H38N4O6 |
| Molecular Weight | 526.6245 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
DescriptionSources: http://www.chemdrug.com/article/8/3285/16420800.html
Sources: http://www.chemdrug.com/article/8/3285/16420800.html
Iganidipin is a new dihydropiridynic derivative of calcium antagonist. It is the only currently available calcium antagonist in the form of ophthalmic solution. Its topical administration increases ipsilateral optic nerve head blood flow in rabbits and monkeys and inhibits the contraction of blood vessels induced by endothelin -1. Iganidipin is also used for treat Angina pectoris and Hypertension.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2363032 Sources: http://www.ncbi.nlm.nih.gov/pubmed/7575741 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
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| Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/12601046
for rabbit: (14)C-iganidipine solution (0.03%, 30 microL) was instilled into one eye
Route of Administration:
Topical
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/16413513
Iganidipine (0.01-1 microM) increased the retinal ganglion cells (RGC) viability
| Substance Class |
Chemical
Created
by
admin
on
Edited
Tue Apr 01 16:25:21 GMT 2025
by
admin
on
Tue Apr 01 16:25:21 GMT 2025
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| Record UNII |
ZU9QD72G5Z
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| Record Status |
Validated (UNII)
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admin on Tue Apr 01 16:25:21 GMT 2025 , Edited by admin on Tue Apr 01 16:25:21 GMT 2025
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| Related Record | Type | Details | ||
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RACEMATE -> ENANTIOMER | |||
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ENANTIOMER -> ENANTIOMER |
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