O-NITROANISOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H7NO3
Molecular Weight	153.1354
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=CC=C1[N+]([O-])=O

InChI

InChIKey=CFBYEGUGFPZCNF-UHFFFAOYSA-N

InChI=1S/C7H7NO3/c1-11-7-5-3-2-4-6(7)8(9)10/h2-5H,1H3

HIDE SMILES / InChI

Molecular Formula	C7H7NO3
Molecular Weight	153.1354
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Early Detection of Genotoxic Urinary Bladder Carcinogens by Immunohistochemistry for γ-H2AX.	2015-12	26338220
Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.	2010	21187827
Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)-hydroxylamine with deoxyguanosine in DNA.	2009-03	21217841
Rat cytochromes P450 oxidize 2-nitrophenol, a human metabolite of carcinogenic 2-nitroanisole.	2009	20027144
Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole.	2008-12	21218119
Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes.	2008-09	21218109
Structure and performance of silica-based monolithic HPLC columns.	2008-08	18618471
In vivo Comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds.	2007-06-15	17507283
Tumorigenic potential and the molecular mechanism of the carcinogenic effect exerted by 2-nitroanisole.	2007-01-05	17201134
Oxidative detoxication of carcinogenic 2-nitroanisole by human, rat and rabbit cytochrome P450.	2006-12	17159769
Carcinogenic pollutants o-nitroanisole and o-anisidine are substrates and inducers of cytochromes P450.	2005-12	16601807
Association of liver hemangiosarcoma and secondary iron overload in B6C3F1 mice--the National Toxicology Program experience.	2004-06-18	15200160
Enzymes involved in the metabolism of the carcinogen 2-nitroanisole: evidence for its oxidative detoxication by human cytochromes P450.	2004-05	15144223
Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans.	2004-05	14729594
o-Nitroanisole.	2004	21089917
3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases.	2002-10-16	12371853
o-Nitroanisole.	2002	15326685
Transcriptional activation of stress genes and cytotoxicity in human liver carcinoma cells (HepG2) exposed to 2,4,6-trinitrotoluene, 2,4-dinitrotoluene, and 2,6-dinitrotoluene.	2001-06	11409192
Synthesis and antibacterial activity of 5-nitrofuryl and 3-methoxy-2-nitrophenyl derivatives of 6 beta-aminopenicillanic, 7 beta-aminocephalosporanic and 7 beta-aminodesacetoxy-cephalosporanic acids.	2001	11799847

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:46:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:46:18 GMT 2025`
Record UNII	ZRE7HLZ17K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

2-NITROANISOLE

Preferred Name

English

O-NITROANISOLE

Common Name

English

NSC-5506

Code

English

2-METHOXYNITROBENZENE

Systematic Name

English

NITROANISOLE, O-

Common Name

English

O-NITROBENZENE METHYL ETHER

Common Name

English

2-METHOXY-1-NITROBENZENE

Systematic Name

English

ANISOLE, O-NITRO-

Common Name

English

1-METHOXY-2-NITROBENZENE

Systematic Name

English

O-NITROANISOLE [MI]

Common Name

English

2-NITROANISOLE [HSDB]

Common Name

English

O-METHOXYNITROBENZENE

Common Name

English

O-NITROPHENYL METHYL ETHER

Common Name

English

1-NITRO-2-METHOXYBENZENE

Systematic Name

English

2-NITROANISOLE [IARC]

Common Name

English

2-NITROMETHOXYBENZENE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C45179