Elritercept

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 15:08:04 GMT 2025` Edited by `admin` on `Wed Apr 02 15:08:04 GMT 2025`
Protein Type	FUSION PROTEINS
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	ZNC37E4KAK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KER-050

Preferred Name

English

Elritercept

Official Name

English

elritercept [INN]

Common Name

English

1-109-Activin receptor type IIA (human construct KER-050) fusion protein with peptide linker (GGG) fusion protein with immunoglobulin G1 [de-339-lysine] (human ?1-chain C-terminal fragment), dimer

Common Name

English

Human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) extracellular domain (ECD) fragment (1-109) engineered variant (F<sup>15>Y</sup>, <sup>21</sup>KD<sup>22</sup>>LE, P<sup>31</sup>>R, Y<sup>33</sup>>E, D<sup>35</sup>>E, R<sup>40</sup>>

Common Name

English

ELRITERCEPT [USAN]

Common Name

English

KER050

Code

English

KER-050 (ActRIIA/B-Fc)

Code

English

Code System Code Type Description

CAS

2727114-26-1

Created by admin on Wed Apr 02 15:08:04 GMT 2025 , Edited by admin on Wed Apr 02 15:08:04 GMT 2025

PRIMARY

NCI_THESAURUS

C199201

Created by admin on Wed Apr 02 15:08:04 GMT 2025 , Edited by admin on Wed Apr 02 15:08:04 GMT 2025

PRIMARY

SMS_ID

300000035010

Created by admin on Wed Apr 02 15:08:04 GMT 2025 , Edited by admin on Wed Apr 02 15:08:04 GMT 2025

PRIMARY

FDA UNII

ZNC37E4KAK

Created by admin on Wed Apr 02 15:08:04 GMT 2025 , Edited by admin on Wed Apr 02 15:08:04 GMT 2025

PRIMARY

USAN

MN-15

Created by admin on Wed Apr 02 15:08:04 GMT 2025 , Edited by admin on Wed Apr 02 15:08:04 GMT 2025

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INN

12526

Created by admin on Wed Apr 02 15:08:04 GMT 2025 , Edited by admin on Wed Apr 02 15:08:04 GMT 2025

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From	To
1_259	1_317
2_259	2_317
1_153	1_213
2_153	2_213
1_118	1_121
2_118	2_121
1_86	1_92
2_86	2_92
1_73	1_85
2_73	2_85
1_67	1_87
2_67	2_87
1_32	1_60
2_32	2_60
1_12	1_42
2_12	2_42

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_25
N	1_48
N	1_189
N	2_25
N	2_48
N	2_189
O	1_97
O	1_108
O	1_109
O	1_115
O	1_117
O	2_97
O	2_108
O	2_109
O	2_115
O	2_117

Related Record Type Details


					ZNC37E4KAK

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL		C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL