FLUOROFORM

Details

Stereochemistry	ACHIRAL
Molecular Formula	CHF3
Molecular Weight	70.0138
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC(F)F

InChI

InChIKey=XPDWGBQVDMORPB-UHFFFAOYSA-N

InChI=1S/CHF3/c2-1(3)4/h1H

HIDE SMILES / InChI

Molecular Formula	CHF3
Molecular Weight	70.0138
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Effect of trimethylsilyl substitution on the chemical properties of triarylphosphines and their corresponding metal-complexes: solubilising effect in supercritical carbon dioxide.	2004-08-21	15303177
Synthesis and biological evaluation of novel T-type Ca2+ channel blockers.	2004-08-01	15246072
Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position.	2004-06-01	15142558
Freon (CHF3)-assisted atomization for the determination of titanium using ultrasonic slurry sampling-graphite furnace atomic absorption spectrometry (USS-GFAAS): a simple and advantageous method for solid samples.	2004-06	15071714
Fluoroartemisinin: trifluoromethyl analogues of artemether and artesunate.	2004-05-06	15115411
Halogenation of drugs enhances membrane binding and permeation.	2004-05-03	15122640
Intramolecular vibrational energy redistribution in the highly excited fluoroform molecule: a quantum mechanical study using the multiconfiguration time-dependent Hartree algorithm.	2004-04-15	15267599
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists.	2004-04-05	15026074
Elimination of R-H from iridium acyl hydrides without loss of CO: evidence for the intervention of metal cation/carbanion pairs.	2004-03-24	15025464
Anticonvulsant activity of phenylmethylenehydantoins: a structure-activity relationship study.	2004-03-11	14998338
Theoretical study of the spin trapping of hydroxyl radical by cyclic nitrones: a density functional theory approach.	2004-02-18	14871114
Mechanism of homogeneous Ir(III) catalyzed regioselective arylation of olefins.	2004-01-14	14709102
Riboflavin synthase of Schizosaccharomyces pombe. Protein dynamics revealed by 19F NMR protein perturbation experiments.	2003-12-23	14690539
Early transition-metal perfluoroalkyl complexes.	2003-12-03	14640639
Synthesis, characterization, and autoreduction of a highly electron-deficient porphycenatoiron(III) with trifluoromethyl substituents.	2003-11-17	14606820
Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.	2003-11-06	14584940
Homoleptic cyclometalated iridium complexes with highly efficient red phosphorescence and application to organic light-emitting diode.	2003-10-22	14558846
Electronically tuned chiral ruthenium porphyrins: extremely stable and selective catalysts for asymmetric epoxidation and cyclopropanation.	2003-10-06	14566882
Alkoxide- and hydroxide-induced nucleophilic trifluoromethylation using trifluoromethyl sulfone or sulfoxide.	2003-09-04	12943400
Highly potent 1,4-benzothiazine derivatives as K(ATP)-channel openers.	2003-08-14	12904071
phi-Values beyond the ribosomally encoded amino acids: kinetic and thermodynamic consequences of incorporating trifluoromethyl amino acids in a globular protein.	2003-08-06	12889945
Efficient and stereoselective synthesis of beta-trifluoromethyl alpha,beta-unsaturated esters via iron(III) porphyrin-catalyzed olefination of ketones.	2003-07-25	12868927
Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones.	2003-05-30	12762751
Origins of inward torquoselectivity by silyl groups and other sigma-acceptors in electrocyclic reactions of cyclobutenes.	2003-04-30	12708857
Highly regioselective hydrogenolysis of bis(alpha-methylbenzyl)amine derivatives affected by the trifluoromethyl substituent on the aromatic ring.	2003-04-03	12659560
Alkylation of manganese(II) tetraphenylporphyrin by antimalarial fluorinated artemisinin derivatives.	2003-03-24	12643911
In the first proven SN2' fullerene reaction, both C3 and C1 C60F36 hydrolyse to C1 isomers of C60F35OH that eliminate HF to give epoxides C60F34O; C60F36O oxides are shown to be ethers, and a fourth isomer of C60F36 exists.	2003-03-21	12929643
New fluorinated derivatives as esterase inhibitors. Synthesis, hydration and crossed specificity studies.	2003-03-20	12614892
Synthesis and characterization of beta-trifluoromethyl-meso-tetraphenylporphyrins.	2003-03-07	12608807
Structure-activity relationships of novel anti-malarial agents: part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides.	2003-02-10	12565929
Synthesis and structures of trifluoromethyl-, fluoro-, and azido-substituted hexabenzylhexaazaisowurtzitanes and isolation of a novel hexaazaisowurtzitane-based polycycle.	2003-02-03	12569461
Design, synthesis and structure-activity relationships of a series of 9-substituted adenine derivatives as selective phosphodiesterase type-4 inhibitors.	2003-02	12620664
End-to-end correlation for a C-12 hydrocarbon chain.	2003-02	12615159
Decomposition of environmentally persistent trifluoroacetic acid to fluoride ions by a homogeneous photocatalyst in water.	2003-01-15	12564917
Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis.	2003-01-08	12515518
Novel trifluoromethyl ketones as potent gastric lipase inhibitors.	2003-01-03	12512081
N-(trifluoromethyl)benzyl substituted N-normetazocines and N-norketobemidones.	2003-01-02	12467704
Examination of 19F-NMR as a tool for investigation of drug-cyclodextrin complexes.	2003-01	12602498
Stereospecific substitution at alpha-carbon to trifluoromethyl group: application to optically active fluorinated amino acid syntheses.	2003-01	12467035
Nucleophilic addition of nitrones to ketones: development of a new catalytic asymmetric nitrone-aldol reaction.	2002-12-16	12693046
Synthesis, crystal structures, and redox potentials of 2,3,12,13-tetrasubstituted 5,10,15,20-tetraphenylporphyrin zinc(II) complexes.	2002-12-16	12470065
Trifluoromethyl ketones as inhibitors of histone deacetylase.	2002-12-02	12419380
Synthesis, antiprotozoal and anticancer activity of substituted 2-trifluoromethyl- and 2-pentafluoroethylbenzimidazoles.	2002-12	12660022
Enantioselective reduction of trifluoromethyl ketones with chiral organomagnesium amides (COMAs).	2002-11-14	12423106
On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings.	2002-11-14	12423091
A first comparative study of purpurinimide-based fluorinated vs. nonfluorinated photosensitizers for photodynamic therapy.	2002-11	12462653
How electron flow controls the thermochemistry of the addition of olefins to nickel dithiolenes: predictions by density functional theory.	2002-10-16	12371830
Blue shifting hydrogen bonding in the complexes of chlorofluoro haloforms with acetone-d(6) and oxirane-d(4).	2002-10-09	12358521
Neutralization of methyl cation via chemical reactions in low-energy ion-surface collisions with fluorocarbon and hydrocarbon self-assembled monolayer films.	2002-10	12387320
Reversible activity changes of lipid-coated lipase for enantioselective esterification in supercritical fluoroform.	2001-09-21	12240337

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:54:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:54:41 GMT 2025`
Record UNII	ZJ51L9A260
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIFLUOROMETHANE

Preferred Name

English

FLUOROFORM

Systematic Name

English

HFC-23

Common Name

English

TRIFLUOROMETHANE [HSDB]

Common Name

English

FLUOROFORM [MI]

Common Name

English

FREON 23

Common Name

English

METHYL TRIFLUORIDE

Common Name

English

HFC 23

Common Name

English

Code System Code Type Description

CHEBI

41550