MANTABEGRON

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H27NO2
Molecular Weight	301.4232
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MANTABEGRON

Structure Search

SMILES

OC(CNC12CC3CC(CC(C3)C1)C2)COC4=CC=CC=C4

InChI

InChIKey=OVHWFGPUZGJWAI-UHFFFAOYSA-N

InChI=1S/C19H27NO2/c21-17(13-22-18-4-2-1-3-5-18)12-20-19-9-14-6-15(10-19)8-16(7-14)11-19/h1-5,14-17,20-21H,6-13H2

HIDE SMILES / InChI

Molecular Formula	C19H27NO2
Molecular Weight	301.4232
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.who.int/medicines/services/inn/StemBook2009.pdf

Mantabegron is an adamantane derivative with β3-adrenoreceptor agonist activity.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Beta-3 adrenergic receptor 54 Target ID: CHEMBL246 Sources: https://www.who.int/medicines/services/inn/StemBook2009.pdf	Agonist 2752

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:55 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:55 GMT 2025`
Record UNII	ZGE26V53PT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

mantabegron [INN]

Preferred Name

English

MANTABEGRON

Official Name

English

(2RS)-1-(ADAMANTAN-1-YLAMINO)-3-PHENOXYPROPAN-2-OL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

Code System Code Type Description

SMS_ID

300000036846

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

EPA CompTox

DTXSID30865806

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

FDA UNII

ZGE26V53PT

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

ChEMBL

CHEMBL2107758

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

PUBCHEM

213044

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

NCI_THESAURUS

C83905

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

CAS

36144-08-8

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

INN

8283

Created by admin on Mon Mar 31 18:38:55 GMT 2025 , Edited by admin on Mon Mar 31 18:38:55 GMT 2025

PRIMARY

Related Record Type Details


					JL556DLY6M

MANTABEGRON HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					ZGE26V53PT

ACTIVE MOIETY