U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Tue Apr 01 21:52:29 GMT 2025
Edited
by admin
on Tue Apr 01 21:52:29 GMT 2025
Protein Type RECEPTOR
Protein Sub Type Other
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
ZFQG2GI3F2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROTEIN-TYROSINE PHOSPHATASE 1D
Preferred Name English
TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11
Common Name English
PTPN11
Common Name English
SH-PTP3
Common Name English
PROTEIN-TYROSINE PHOSPHATASE 2C
Common Name English
PTP2C
Common Name English
SHPTP2
Common Name English
SHP2
Common Name English
Code System Code Type Description
CAS
301156-53-6
Created by admin on Tue Apr 01 21:52:29 GMT 2025 , Edited by admin on Tue Apr 01 21:52:29 GMT 2025
PRIMARY
FDA UNII
ZFQG2GI3F2
Created by admin on Tue Apr 01 21:52:29 GMT 2025 , Edited by admin on Tue Apr 01 21:52:29 GMT 2025
PRIMARY
UNIPROT
Q06124
Created by admin on Tue Apr 01 21:52:29 GMT 2025 , Edited by admin on Tue Apr 01 21:52:29 GMT 2025
PRIMARY
Related Record Type Details
ALLOSTERIC INHIBITOR->TARGET
IN-VITRO
IC50
ACTIVATOR->OFF TARGET
Kd
INHIBITOR -> TARGET
INHIBITOR -> TARGET
ALLOSTERIC INHIBITOR
INHIBITOR -> TARGET
Greatly reduced effect in the SHP2 E76K or T253M/Q257L mutants.
ALLOSTERIC
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] N-TERMINUS N-ACETYLTHREONINE V0E98V3R9O
AMINO_ACID_SUBSTITUTION [1_61] [1_65] [1_545] [1_583] SITE_SPECIFIC TYROSINE O-PHOSPHATE 2R86C98KDX
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL