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REVUSIRAN
ZE6EHM8Z3A
Investigational
General
Record Details
Names
4
Classification
2
Identifiers
5
Subunits
2
Sugars
2
Linkages
2
Modifications
3
REVUSIRAN
ZE6EHM8Z3A
Investigational
General
Approval Year
Unknown
139,594
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Subtype
Sequence Type
OLIGONUCLEOTIDE
Record UNII
ZE6EHM8Z3A
Record Status
Validated (UNII)
Record Version
13
12
11
10
9
8
7
6
5
4
3
2
1
Names
4
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5
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entries
Name
Type
Language
Name
Type
Language
REVUSIRAN
Official Name
English
AD-51547
Code
English
revusiran [INN]
Common Name
English
Revusiran [WHO-DD]
Common Name
English
Showing 1 to 4 of 4 entries
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Classification
2
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Designated/Withdrawn
ORPHAN DRUG
Designated/Withdrawn
Treatment of transthyretin amyloidosis
FDA ORPHAN DRUG
477615
Pharmacologic Substance
Pharmacologic Substance
[C1909]
Biological Agent
NCI_THESAURUS
C307
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Identifiers
5
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Code System
Code
Type
Description
Code System
Code
Type
Description
NCI_THESAURUS
C152204
PRIMARY
EVMPD
SUB184392
PRIMARY
CAS
1438322-82-7
PRIMARY
INN
9989
PRIMARY
FDA UNII
ZE6EHM8Z3A
PRIMARY
Showing 1 to 5 of 5 entries
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Subunits
2
Subunit 0
>SUBUNIT_0
Subunit 1
>SUBUNIT_1
Sugars
2
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Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
2'-O-Methyl-Ribose
1_2;1_4;1_6;1_8;1_12;1_14-1_16;1_18;1_20;2_1;2_3;2_5;2_9;2_11-2_13;2_15;2_17;2_19;2_21;2_23
22 / 45
2'-Fluoro-Ribose
1_1;1_3;1_5;1_7;1_9-1_11;1_13;1_17;1_19;1_21-1_22;2_2;2_4;2_6-2_8;2_10;2_14;2_16;2_18;2_20;2_22
23 / 45
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Linkages
2
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Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Phosporothioate
2_22-2_23
2 / 43
Phosphate
1_2-1_22;2_2-2_21
41 / 43
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Modifications
3
Agent Modifications
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Modification Process
Modification Role
Modification Type
Amount
Fragment Name
Fragment ID
Modification Process
Modification Role
Modification Type
Amount
Fragment Name
Fragment ID
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Physical Modifications
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Modification Role
Parameter Name
Amount
Modification Role
Parameter Name
Amount
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Structural Modifications
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Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
NUCLEOTIDE SUBSTITUTION
[1_22]
3'-TERMINUS
CEMDISIRAN, TERMINAL SUGAR MODIFICATION-
CQQ59545BV
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