REVUSIRAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 09:40:15 UTC 2023` Edited by `admin` on `Sat Dec 16 09:40:15 UTC 2023`
Nucleic Acid Subtype
Sequence Type	OLIGONUCLEOTIDE
Record UNII	ZE6EHM8Z3A
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

REVUSIRAN

Official Name

English

AD-51547

Code

English

revusiran [INN]

Common Name

English

Revusiran [WHO-DD]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

477615

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

NCI_THESAURUS

C307

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

Code System Code Type Description

NCI_THESAURUS

C152204

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

PRIMARY

EVMPD

SUB184392

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

PRIMARY

CAS

1438322-82-7

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

PRIMARY

INN

9989

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

PRIMARY

FDA UNII

ZE6EHM8Z3A

Created by admin on Sat Dec 16 09:40:15 UTC 2023 , Edited by admin on Sat Dec 16 09:40:15 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_2;1_4;1_6;1_8;1_12;1_14-1_16;1_18;1_20;2_1;2_3;2_5;2_9;2_11-2_13;2_15;2_17;2_19;2_21;2_23	22 / 45
2'-Fluoro-Ribose	1_1;1_3;1_5;1_7;1_9-1_11;1_13;1_17;1_19;1_21-1_22;2_2;2_4;2_6-2_8;2_10;2_14;2_16;2_18;2_20;2_22	23 / 45

Linkage	Site Range	Site Count
Phosporothioate	2_22-2_23	2 / 43
Phosphate	1_2-1_22;2_2-2_21	41 / 43

Agent Modifications

Modification Process	Modification Role	Modification Type	Amount	Fragment Name	Fragment ID

Physical Modifications

Modification Role	Parameter Name	Amount

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_22]	3'-TERMINUS			CEMDISIRAN, TERMINAL SUGAR MODIFICATION-	CQQ59545BV