DONIDALORSEN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 14:35:56 GMT 2023` Edited by `admin` on `Sat Dec 16 14:35:56 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	ZD4D8M32TL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DONIDALORSEN

Official Name

English

DNA, D((2'-O-(2-METHOXYETHYL))M5RU-SP-(2'-O-(2-METHOXYETHYL))RG-SP-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RA-SP-G-SP-T-SP-M5C-SP-T-SP-M5C-SP-T-SP-T-SP-G-SP-G-SP-M5C-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL)

Common Name

English

donidalorsen [INN]

Common Name

English

ISIS-721744 FREE ACID

Code

English

DONIDALORSEN [USAN]

Common Name

English

Code System Code Type Description

USAN

HI-37

Created by admin on Sat Dec 16 14:35:56 GMT 2023 , Edited by admin on Sat Dec 16 14:35:56 GMT 2023

PRIMARY

INN

11653

Created by admin on Sat Dec 16 14:35:56 GMT 2023 , Edited by admin on Sat Dec 16 14:35:56 GMT 2023

PRIMARY

CAS

2304692-48-4

Created by admin on Sat Dec 16 14:35:56 GMT 2023 , Edited by admin on Sat Dec 16 14:35:56 GMT 2023

PRIMARY

NCI_THESAURUS

C177101

Created by admin on Sat Dec 16 14:35:56 GMT 2023 , Edited by admin on Sat Dec 16 14:35:56 GMT 2023

PRIMARY

FDA UNII

ZD4D8M32TL

Created by admin on Sat Dec 16 14:35:56 GMT 2023 , Edited by admin on Sat Dec 16 14:35:56 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_5;1_16-1_20	10 / 20
Deoxyribose (DNA)	1_6-1_15	10 / 20

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_3;1_6-1_16;1_19-1_20	15 / 19
Phosphate	1_4-1_5;1_17-1_18	4 / 19

Related Record Type Details


					ZD4D8M32TL

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_3] [1_8] [1_10] [1_15] [1_19]	SITE_SPECIFIC			5-METHYLCYTIDINE	TL9PB228DC